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Lab Dept:
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Chemistry
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Test Name:
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5-FLUORoCYTOSINE LEVEL
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General Information
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Lab Order Codes:
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5FC
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Synonyms:
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Antifungal Level, Fluorcytosine
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CPT Codes:
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80299 – Quantitation of drug; not elsewhere specified
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Test Includes:
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5-Fluorocytosine level reported in ug/mL.
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Logistics
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Test Indications:
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This anti-fungal drug is ordinarily used with amphotercin B for life-threatening fungal infections, such as fungal meningitis or other invasive disease.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Fairview University Diagnostic Laboratories (Test: 5CFL)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test performed Monday - Friday
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Special Instructions:
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May be tested in the presence of amphotericin B. Specify other antifungal agents patient is currently receiving; some antifungal agents cannot be tested in the presence of others. To reduce turnaround, notify laboratory as soon as intent to collect titer is known so organism can be prepared.
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Specimen
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Specimen Type:
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Whole blood, CSF or other body fluid
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Container:
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Collect blood in red top tube (plain, no gel); collect CSF or fluid in sterile container.
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Draw Volume:
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Blood: 3 mL (Minimum: 1.2 mL)
CSF or fluid: 1 mL (Minimum: 0.5 mL)
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Processed Volume:
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Serum: 1.0 mL (Minimum 0.5 mL)
CSF or fluid: 1.0 mL (Minimum 0.5 mL)
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Collection:
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Designate which specimens are peak and trough. Trough specimens are collected just prior to the next dose. Peak specimen collections should be collected 1 ½ - 2 hours after oral dose.
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Special Processing:
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Lab Staff: Centrifuge blood and aliquot) serum. Store in refrigerator. Ship at room temperature. Specimen must arrive within 24 hours of collection.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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25 - 80 ug/mL; 40 - 60 ug/mL is optimal
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Critical Values:
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>100 µg/mL may be toxic
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Limitations:
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N/A
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Methodology:
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Bioassay
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Contraindications:
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Patient receiving Amphotericin B or Ketoconazole simultaneously will interfere with assay.
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References:
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Fairview University Diagnostic Laboratories Laboratory Web Page http://labguide.fairview.org/diagnostic.asp (September 2009)
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