Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

BUPROPION LEVEL

General Information

Lab Order Codes:

BUP

Synonyms:

WellbutrinŽ, ZybanŽ

CPT Codes:

82492 - Chromatography, quantitative, column; multiple analytes, single stationary and mobile phase

Test Includes:

Bupropion and Hydroxybupropion levels reported in ng/mL.

Logistics

Test Indications:

Monitoring of Bupropion levels

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (Test:178)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 day

Special Instructions:

SST tubes are not acceptable. Trough levels are most reproducible.

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) or Green top (Li Heparin) tube

Draw Volume:

9 mL (Minimum: 2 mL) blood

Processed Volume:

3 mL (Minimum: 0.6 mL) serum or plasma

NOTE: Submission of the minimum volume results in an elevated reporting limit and inability to repeat testing.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot. Freeze immediately and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimen drawn in an SST tube; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Bupropion:

50 - 100 ng/mL

Hydroxybupropion:

600 – 2000 ng/mL

Critical Values:

Bupropion: >300 ng/mL

Limitations:

Bupropion reporting limit:

5 ng/mL

Hydroxybupropion reporting limit:

100 ng/mL

Methodology:

High Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV)

References:

Medtox Web Page (July 2006) www.medtox.com



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