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Lab Dept:
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Chemistry
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Test Name:
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BUPROPION LEVEL
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General Information
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Lab Order Codes:
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BUP
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Synonyms:
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WellbutrinŽ, ZybanŽ
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CPT Codes:
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82492 - Chromatography, quantitative, column; multiple analytes, single stationary and mobile phase
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Test Includes:
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Bupropion and Hydroxybupropion levels reported in ng/mL.
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Logistics
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Test Indications:
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Monitoring of Bupropion levels
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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MedTox Laboratories (Test# 178)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 day
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Special Instructions:
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SST tubes are not acceptable. Trough levels are most reproducible.
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Red top (plain, no gel) or Green top (Li Heparin) tube
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Draw Volume:
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9.0 mL (Minimum: 2.0 mL) blood
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Processed Volume:
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3.0 mL (Minimum: 0.6 mL) serum or plasma
NOTE: Submission of the minimum volume results in an elevated reporting limit and inability to repeat testing.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot. Freeze immediately and ship at frozen temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimen drawn in an SST tube, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Bupropion:
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50 - 100 ng/mL
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Hydroxybupropion:
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600 – 2000 ng/mL
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Critical Values:
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Bupropion: >300 ng/mL
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Limitations:
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Bupropion reporting limit:
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5 ng/mL
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Hydroxybupropion reporting limit:
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100 ng/mL
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Methodology:
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High Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV)
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Contraindications:
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N/A
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References:
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Medtox Web Page (July 2006) www.medtox.com
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