Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

BUPIVACAINE LEVEL

General Information

Lab Order Codes:

BUPI

Synonyms:

MarcaineŽ

CPT Codes:

80299 – Quantitation of drug, not elsewhere specified

Test Includes:

Bupivicaine concentration measured in mcg/mL.

Logistics

Test Indications:

Useful to monitor therapeutic concentration. Assessment of possible CNS or cardiac toxicity associated with use of bupivacaine or levobupivacaine.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 89548/BUPIS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 8 days, performed Monday

Special Instructions:

See Limitations

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

4.5 mL (Minimum: 1.8 mL) blood

Processed Volume:

1.5 mL (Minimum: 0.6 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot. Store and ship specimen at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

No established reference values

Critical Values:

N/A

Limitations:

This assay is to be used for only serum drawn from a vein. Arterial levels are approximately twice venous levels and no clear relationship between arterial levels and toxicity has been established.

This assay measures only total bupivacaine; levels of the free (unbound) portion may correlate more closely with symptoms.

Methodology:

Gas Chromatography-Mass Spectrometry (GC-MS)

References:

Mayo Medical Laboratories Web Page (May 2009)

Updates:

5/18/2009: Mayo moved test from a forward to MedTox to being performed internally at MML. Previously test: 91093



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