Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

ETHOTOIN LEVEL

General Information

Lab Order Codes:

ETH

Synonyms:

Peganone®

CPT Codes:

82491 - Chromatography, quantitative, column; single analyte not elsewhere specified, single stationary and mobile phase

Test Includes:

Ethotoin concentration measured in ug/mL.

Logistics

Test Indications:

Assessment of compliance, therapeutic drug monitoring.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (MedTox Test: 49)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 days

Special Instructions:

Trough levels are most reproducible.

Specimen

Specimen Type:

Blood

Container:

Red top tube preferred

Alternate: Green (Na Heparin) tube (obtain from the laboratory).

Draw Volume:

6 mL (Minimum: 0.6 mL) blood

Processed Volume:

2 mL (Minimum: 0.2 mL) serum/plasma

Note: Submission of the minimum volume results in an elevated reporting limit and inability to repeat analysis

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

8.0 – 20.0 ug/mL

Note: The therapeutic range for ethotoin is not well established. Many patients respond well to ethotoin concentrations up to 60 µg/mL.

Critical Values:

>60.0 ug/mL

Limitations:

Reporting limit: 1.0 ug/mL

Methodology:

Gas Chromatography/Flame ionization Detection (GC-FID)

References:

MedTox Laboratories Web Page June 2011



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