Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

LAMICTAL LEVEL

General Information

Lab Order Codes:

LAMM

Synonyms:

Lamotrigine

CPT Codes:

82491- Chromatography, quantitative, column; single analyte not elsewhere specified, single stationary and mobile phase

Test Includes:

Lamictal level reported in ug/mL.

Logistics

Test Indications:

Monitoring serum concentration of lamictal (lamotrigine), assessing compliance or adjusting lamotrigine dose in patients receiving other anticonvulsant drugs which interact pharmokinetically with lamictal (lamotrigine).

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (MedTox Test:158)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 2 days, test performed daily

Special Instructions:

If this is a STAT order, please check with the provider to see if the specimen should be shipped immediately and performed STAT by the reference lab at an additional cost. If immediate shipment is necessary, please call the lab to make arrangements.

Specimen

Specimen Type:

Blood

Container:

Red top tube
Alternate: Green (Lithium Heparin) tube

Draw Volume:

6 mL (Minimum: 1 mL) blood

Processed Volume:

2 mL (Minimum: 0.3 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

2 – 20 ug/mL

Note: Current clinical information suggests the recommended concentrations for lamotrigine during chronic therapy are 2 - 20 ug/mL.

Critical Values:

N/A

Limitations:

Reporting Limit: 0.5 ug/mL

Methodology:

MedTox: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

References:

MedTox Laboratories December 2010

Updates:

6/11/2004: Test moved from MedTox to Mayo Medical Laboratories. Change in ref range from 2.0 – 20.0 ug/mL to 1 – 4 ug/mL.
3/31/2009: Ref range/units change, previously listed as 1-4 ug/mL.
9/27/2010: Method change. Previously listed as HPLC for Mayo.
12/7/2010: Mayo references removed. All testing MedTox.



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