Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

GROWTH HORMONE, SINGLE, SERUM

General Information

Lab Order Codes:

HGH

Synonyms:

HGH; Somatotropin

CPT Codes:

83003 - Growth hormone, human (HGH)

Test Includes:

Single growth hormone level reported in ng/mL.

Logistics

Test Indications:

Excess Growth Hormone secretion is associated with acromegaly in adults or pituitary gigantism in children, while a deficiency may cause short stature in children.

Lab Testing Sections:

Chemistry (St. Paul Campus)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test performed Monday - Friday

Special Instructions:

Follow physician’s protocol for administering provocative stimuli and drawing specimens. See Patient Preparation.

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube

Draw Volume:

1.5 mL (Minimum: 0.6 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.2 mL) serum

Collection:

Routine venipuncture or line draw

Special Processing:

Lab Staff: Centrifuge specimen within 1 hour of draw, remove serum aliquot into a screw-capped round bottom plastic vial. Freeze immediately. Ship to St. Paul frozen.

Patient Preparation:

See Special Instructions. In addition, patient must be fasting and at
complete rest 30 minutes before blood collection.

Sample Rejection:

Mislabeled or unlabeled specimens; improper storage; gross hemolysis; improper storage

Interpretive

Reference Range:

Age

Result Range

0 - 1 day

5 - 53 ng/mL

1 day - 1 week

5 - 27 ng/mL

2 weeks - 12 months

2 - 10 ng/mL

>12 months:

0 – 6 ng/mL

Response Testing (Children and Adults):

Following provocative stimuli, a normal response is a rise to 10 ng/mL or greater. Intermediate values between 7 ng/mL and 10 ng/mL may indicate a partial deficiency and require further evaluation.

Critical Values:

N/A

Limitations:

Patients on hGH therapy may develop human antibodies to hGH that will interfere with the test and cause falsely low levels.

Methodology:

Chemiluminescent competitive immunoassay

References:

DPC End User Procedure Manual Disk #0408111 (2005)

Siemens Immulite Recombinant 98/574 hGH product insert (09/08/2010) PIL2KGRH-7

National Committee for Clinical Laboratory Standards (NCCLS) (2002) Clinical Laboratory Technical Procedure Manuals; Approved Guideline-Fourth Edition GP2-A4

Expected Values and S.I. Unit Conversion Tables, 2nd Edition, Endocrine Sciences, 4301 Lost Hills Rd, Calabasas Hills, CA 91301

Biorad Immunoassay Plus Control Product Insert

Burtis, CA, Ashwood, ER, Bruns, DE, ed (2006) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th Edition, Philadelphia: W.B. Saunders

Jacobs and DeMott Laboratory Test handbook (2001) 5th Edition, Lexi-comp Inc



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