Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

ACID PHOSPHATASE, PROSTATE FRACTIONATION

General Information

Lab Order Codes:

ACPP

Synonyms:

Prostate Acid Phosphatase (PAP) Serum

CPT Codes:

84066 – Phosphatase, acid; prostatic

Test Includes:

Prostate Acid Phosphatase level reported in ng/mL.

Logistics

Test Indications:

Predicting recurrence after radial prostatectomy for clinically localized prostate cancer and following response to androgen ablation therapy, when used in conjunction with PSA.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8019/PACP)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test set up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.2 mL) blood

Processed Volume:

1 mL (Minimum: 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship frozen. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum or heparin plasma; hemolyzed specimen; warm specimens, mislabeled or unlabeled specimens

Interpretive

Reference Range:

≤2.1 ng/mL

Note: Serum markers are not specific for malignancy and values may vary by method.

Critical Values:

N/A

Limitations:

Prostatic Acid Phosphatase (PAP) must not be regarded as an absolute test for malignancy since other factors, including benign prostatic hyperplasia, prostatic infarction, and manipulation of the prostate gland may result in elevated serum PAP concentration.

PAP measurements provide little additional information beyond that provided by PSA measurements.

Human anti-mouse antibodies (HAMA) may be present in specimens from patients who have received immunotherapy utilizing monoclonal antibodies. Other heterophile antibodies also may be present in patient specimens. This assay has been specifically formulated to minimize the effects of these antibodies on the assay. However, carefully evaluate results from patients known to have such antibodies.

Methodology:

Automated Chemiluminometric Immunometric Assay

References:

Mayo Medical Laboratories Web Page (February 2010)



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