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Lab Dept:
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Chemistry
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Test Name:
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ACID PHOSPHATASE, PROSTATE FRACTIONATION
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General Information
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Lab Order Codes:
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ACPP
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Synonyms:
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Prostate Acid Phosphatase (PAP) Serum
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CPT Codes:
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84066 – Phosphatase, acid; prostatic
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Test Includes:
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Prostate Acid Phosphatase level reported in ng/mL.
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Logistics
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Test Indications:
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Predicting recurrence after radial prostatectomy for clinically localized prostate cancer and following response to androgen ablation therapy, when used in conjunction with PSA.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 8019)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test set up Monday - Saturday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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3.0 mL (Minimum: 1.0 mL) blood
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Processed Volume:
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1.0 mL (Minimum: 0.4 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship frozen. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum or heparin plasma, hemolyzed specimen, warm specimens, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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≤2.1 ng/mL
Note: Serum markers are not specific for malignancy and values may vary by method.
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Critical Values:
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N/A
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Limitations:
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Prostatic Acid Phosphatase (PAP) must not be regarded as an absolute test for malignancy since other factors, including benign prostatic hyperplasia, prostatic infarction, and manipulation of the prostate gland may result in elevated serum PAP concentration.
PAP measurements provide little additional information beyond that provided by PSA measurements.
Human anti-mouse antibodies (HAMA) may be present in specimens from patients who have received immunotherapy utilizing monoclonal antibodies. Other heterophile antibodies also may be present in patient specimens. This assay has been specifically formulated to minimize the effects of these antibodies on the assay. However, carefully evaluate results from patients known to have such antibodies.
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Methodology:
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Automated Chemiluminometric Immunometric Assay
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References:
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Mayo Medical Laboratories Web Page (February 2010)
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