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Lab Dept:
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Chemistry
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Test Name:
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AMIODARONE LEVEL
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General Information
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Lab Order Codes:
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AMI
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Synonyms:
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Cordarone®; Desethylamiodarone
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CPT Codes:
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82492 – Chromatography, quantitative, column, multiple analytes not elsewhere specified, single stationary and mobile phase
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Test Includes:
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Amiodarone and Desethylamiodarone concentrations in ng/mL.
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Logistics
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Test Indications:
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This test is useful for monitoring adequacy of blood concentration during Amiodarone therapy. The test may also be useful to evaluate patient compliance.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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MedTox Laboratories (Test# 10)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 2 days, test set up daily
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Special Instructions:
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Trough levels should be obtained no less than 12 hours after the last dose.
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Specimen
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Specimen Type:
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Blood
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Container:
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Green top tube, preferred
Alternate: Red top tube
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Draw Volume:
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6.0 mL (Minimum: 1.0 mL) blood
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Processed Volume:
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2.0 mL (Minimum: 0.3 mL) serum/plasma
Note: Submission of the minimum volume results in an elevated reporting range and inability to repeat analysis.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Amiodarone
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500 – 2500 ng/mL
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Desethylamiodarone
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No reference range available
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Critical Values:
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Amiodarone: ≥5000 ng/mL
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Desethylamiodarone: No critical value
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Limitations:
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Amiodarone: Reporting limit 100 ng/mL
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Desethylamiodarone: Reporting limit 100 ng/mL
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Methodology:
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High Performance Liquid Chromatography (HPLC)
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References:
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MedTox Laboratories Web Page (May 2006)
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Updates:
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3/8/2004: Test moved from MedTox Laboratories to Mayo Medical Laboratories. Note: Change in units from ng/mL to µg/mL.
5/31/2006: Test moved from Mayo Medical Laboratories to MedTox Laboratories. Note: Change in units from µg/mL to ng/mL. Tube type change from Lavender to Green/Red.
7/14/2010: Added minimum draw volume.
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