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Lab Dept:
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Chemistry
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Test Name:
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ACETYLCHOLINESTERASE, RBC
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General Information
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Lab Order Codes:
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ACER
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Synonyms:
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Cholinesterase, RBC; RBC Acetyl Cholinesterase; Carbamates
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CPT Codes:
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82482 – Cholinesterase; RBC
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Test Includes:
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Acetylcholinesterase RBC’s level measured in U/g of hemoglobin.
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Logistics
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Test Indications:
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Useful for detecting effects of remote (months) past exposure to cholinesterase inhibitors (organophosphate insecticide poisoning). For more recent exposure, see Pseudocholinesterase.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 8522/ACHS)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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4 - 7 days, test is set up Tuesday and Friday
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Special Instructions:
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EDTA whole blood must arrive at the reference laboratory within 72 hours of collection.
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Lavender top (EDTA) tube
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Draw Volume:
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4 mL (Minimum: 2.5 mL) blood
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Processed Volume:
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Same as Draw Volume. See Special Processing.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Do Not centrifuge. Specimens should remain in the original collection container. Forward promptly. Specimen must arrive at reference laboratory within 72 hours of collection.
Collection date is required on request form.
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Patient Preparation:
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4 hour fast preferred, non-fasting acceptable
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Sample Rejection:
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Specimens other than EDTA whole blood, hemolyzed specimens, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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31.2 – 61.3 U/g of hemoglobin
Note: Activities less than normal are suspect for exposure to certain insecticides.
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Critical Values:
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N/A
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Limitations:
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Make sure the potential offending agent is, indeed, an AChe inhibitor. Pseudocholinesterase activity in serum is the appropriate test for succinylcholine sensitivity to anesthesia.
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Methodology:
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Spectrophotometric-Thiocholine Production
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References:
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Mayo Medical Laboratories Web Page (January 2013)
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Updates:
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1/10/2011: Change in specimen type required, change in reference ranges.
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