Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

IGA, SUBCLASSES

General Information

Lab Order Codes:

IGAS

Synonyms:

IgA Subclasses 1 and 2; IGA1 and IGA2

CPT Codes:

82784 – Gammaglobulin; IgA, IgD, IgG, IgM, each
82787 x2 – Immunoglobulin subclasses

Test Includes:

IgA total, IgA subclass 1, IgA subclass 2 reported in mg/dL.

Logistics

Test Indications:

Evaluate humoral immunity; monitor therapy in IgA myeloma. Selective IgA deficiency has an increased association with allergies, recurrent sinopulmonary infection, autoimmune disease.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: IGAS/87938)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 - 8 days, performed Monday - Thursday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum or plasma; mislabeled or unlabeled specimens

Interpretive

Reference Range:

IgA Subclasses:

Age

IgA1 (mg/dL)

IgA2 (mg/dL)

Total IgA (mg/dL)

0 – 2 years:

18 - 63

3 - 19

25 - 75

3 – 6 years:

25 - 126

2 - 31

31 - 153

7 – 12 yrs:

49 - 183

3 – 43

56 - 232

>12 yrs:

54 - 296

10 - 96

79 - 399

Serum IgA is comprised of 80–90% IgA1 and 10–20% IgA2. Deficiencies in either subclass have been associated with anaphylactic transfusion reactions. Decreased IgA1 levels have been reported in patients with Haemophilus influenzae infection, whereas decreased IgA2 levels have been reported in patients with sinopulmonary infections.

Critical Values:

N/A

Limitations:

N/A

Methodology:

Nephelometry

References:

Mayo Medical Laboratories Web Page (January 2013)

Updates:

3/25/2004: Test moved from Specialty Laboratories to Mayo Medical Laboratories forward to Focus Technologies, Inc. Note: Change in methodology from Nephelometry to RID and change in reference ranges.
7/3/2006: New reference ranges implemented for new nephelometry method at Focus. Previous method, RID.
2/18/13: Test now performed internally at MML.



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