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Lab Dept:
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Chemistry
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Test Name:
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IGA, SUBCLASSES
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General Information
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Lab Order Codes:
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IGAS
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Synonyms:
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IgA Subclasses 1 and 2; IGA1 and IGA2
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CPT Codes:
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82784 – Gammaglobulin; IgA, IgD, IgG, IgM, each
82787 x2 – Immunoglobulin subclasses
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Test Includes:
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IgA total, IgA subclass 1, IgA subclass 2 reported in mg/dL.
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Logistics
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Test Indications:
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Evaluate humoral immunity; monitor therapy in IgA myeloma. Selective IgA deficiency has an increased association with allergies, recurrent sinopulmonary infection, autoimmune disease.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test: IGAS/87938)
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Phone Numbers:
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MIN Lab: 612-813-6280
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STP Lab: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 - 8 days, performed Monday - Thursday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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3 mL (Minimum: 1.5 mL) blood
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Processed Volume:
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1 mL (Minimum: 0.5 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum or plasma; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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IgA Subclasses:
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Age
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IgA1 (mg/dL)
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IgA2 (mg/dL)
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Total IgA (mg/dL)
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0 – 2 years:
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18 - 63
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3 - 19
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25 - 75
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3 – 6 years:
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25 - 126
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2 - 31
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31 - 153
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7 – 12 yrs:
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49 - 183
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3 – 43
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56 - 232
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>12 yrs:
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54 - 296
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10 - 96
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79 - 399
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Serum IgA is comprised of 80–90% IgA1 and 10–20% IgA2. Deficiencies in either subclass have been associated with anaphylactic transfusion reactions. Decreased IgA1 levels have been reported in patients with Haemophilus influenzae infection, whereas decreased IgA2 levels have been reported in patients with sinopulmonary infections.
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Nephelometry
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References:
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Mayo Medical Laboratories Web Page (January 2013)
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Updates:
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3/25/2004: Test moved from Specialty Laboratories to Mayo Medical Laboratories forward to Focus Technologies, Inc. Note: Change in methodology from Nephelometry to RID and change in reference ranges.
7/3/2006: New reference ranges implemented for new nephelometry method at Focus. Previous method, RID.
2/18/13: Test now performed internally at MML.
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