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Lab Dept:
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Chemistry
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Test Name:
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ANDROSTENEDIONE
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General Information
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Lab Order Codes:
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ADRO
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Synonyms:
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N/A
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CPT Codes:
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82157 - Androstenedione
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Test Includes:
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Androstenedione level reported in ng/dL.
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Logistics
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Test Indications:
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Evaluate androgen production in hirsute females; less useful in evaluation of other aspects of virilization. Greatly elevated in the most common type of congenital adrenal hyperplasia due to C21-hydroxylase deficiency, in which in infancy elevated 17-hydroxyprogesterone, progesterone, urinary 17-ketosteroids, renin, and ACTH with low serum cortisol are anticipated. Prenatal diagnosis of congenital adrenal hyperplasia due to 21- hydroxylase deficiency is possible. Laboratory investigation includes measurement of 17-hydroxyprogesterone, androstenedione, testosterone, 21-deoxycortisol and HLA typing. Early diagnosis can now be made with molecular genetic studies from chorionic villus sampling.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Esoterix, Inc. (Test# 500030)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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3 - 6 days, Test set up Monday, Tuesday,Thursday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
Alternate tube: Lavender top (EDTA) tube
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Draw Volume:
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1.5 mL (Minimum: 0.6 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.2 mL) serum/plasma
Note: Submission of the minimum does not permit repeat analysis.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship frozen in plastic vial. Separate within 1 hour of draw. Forward promptly.
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Patient Preparation:
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Fasting morning specimen is preferred. Collect 1 week before or after menstrual period.
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Sample Rejection:
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Recently administered radioisotopes; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Premature Infants
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26-28 weeks, day 4
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63 - 935 ng/dL
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31-35 weeks, day 4
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50 - 449 ng/dL
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Full-Term Infants
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1 - 7 days
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<10 - 279 ng/dL
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Levels decrease rapidly to a range of <52 ng/dL after 1 week.
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1 - 11 months
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<10 - 37 ng/dL
Levels gradually decrease during the first 6 months to prepubertal levels.
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Prepubertal Children
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1-10 years
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<10 - 17 ng/dL
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Tanner Stage
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Puberty
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Male
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Female
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Age (years)
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Range (ng/dL)
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Age (years)
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Range (ng/dL)
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1
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< 9.8
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<10 - 17
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< 9.2
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<10 - 17
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2
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9.8 – 14.5
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<10 - 33
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9.2 – 13.7
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<10 - 72
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3
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10.7 – 15.4
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17 - 72
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10.0 – 14.4
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50 - 170
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4
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11.8 – 16.2
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15 - 115
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10.7 – 15.6
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47 - 208
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5
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12.8 – 17.3
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33 - 192
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11.8 – 18.6
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50 - 224
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Adults (18-40 years)
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Males
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44 - 186 ng/dL
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Females (entire cycle)
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28 - 230 ng/dL
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Females (postmenopausal)
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<10 - 93 ng/dL
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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HPLC Tandem Mass Spectrometry
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References:
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Levine LS and Pang S (1994) “Prenatal Diagnosis and Treatment of Congenital Adrenal Hyperplasia,” J Pediatr Endocrinol, 7(3): 193-200
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Forest MG, David M and Morel Y (1993) “Prenatal Diagnosis and Treatment of 21-Hydroxylase Deficiency,” J Steroid Biochem Mol Biol,45(1-3):75-82
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Esoterix, Inc Web Page April 2012
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Esoterix, Inc. “Expected Value and S.I. Unit Conversion Table” Fifth Edition
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Updates:
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4/17/2012: Updated reference ranges.
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