Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

ANDROSTENEDIONE

General Information

Lab Order Codes:

ADRO

Synonyms:

N/A

CPT Codes:

82157 - Androstenedione

Test Includes:

Androstenedione level reported in ng/dL.

Logistics

Test Indications:

Evaluate androgen production in hirsute females; less useful in evaluation of other aspects of virilization. Greatly elevated in the most common type of congenital adrenal hyperplasia due to C21-hydroxylase deficiency, in which in infancy elevated 17-hydroxyprogesterone, progesterone, urinary 17-ketosteroids, renin, and ACTH with low serum cortisol are anticipated. Prenatal diagnosis of congenital adrenal hyperplasia due to 21- hydroxylase deficiency is possible. Laboratory investigation includes measurement of 17-hydroxyprogesterone, androstenedione, testosterone, 21-deoxycortisol and HLA typing. Early diagnosis can now be made with molecular genetic studies from chorionic villus sampling.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Esoterix, Inc. (Test# 500030)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 - 6 days, Test set up Monday, Tuesday,Thursday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube
Alternate tube: Lavender top (EDTA) tube

Draw Volume:

1.5 mL (Minimum: 0.6 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.2 mL) serum/plasma

Note: Submission of the minimum does not permit repeat analysis.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship frozen in plastic vial. Separate within 1 hour of draw. Forward promptly.

Patient Preparation:

Fasting morning specimen is preferred. Collect 1 week before or after menstrual period.

Sample Rejection:

Recently administered radioisotopes; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Premature Infants

26-28 weeks, day 4

63 - 935 ng/dL

31-35 weeks, day 4

50 - 449 ng/dL

Full-Term Infants

1 - 7 days

<10 - 279 ng/dL

Levels decrease rapidly to a range of <52 ng/dL after 1 week.

1 - 11 months

<10 - 37 ng/dL

Levels gradually decrease during the first 6 months to prepubertal levels.

Prepubertal Children

1-10 years

<10 - 17 ng/dL

Tanner Stage

Puberty

Male

Female

 
 

Age (years)

Range (ng/dL)

Age (years)

Range (ng/dL)

1

< 9.8

<10 - 17

< 9.2

<10 - 17

2

9.8 – 14.5

<10 - 33

9.2 – 13.7

<10 - 72

3

10.7 – 15.4

17 - 72

10.0 – 14.4

50 - 170

4

11.8 – 16.2

15 - 115

10.7 – 15.6

47 - 208

5

12.8 – 17.3

33 - 192

11.8 – 18.6

50 - 224

Adults (18-40 years)

Males

44 - 186 ng/dL

Females (entire cycle)

28 - 230 ng/dL

Females (postmenopausal)

<10 - 93 ng/dL

Critical Values:

N/A

Limitations:

N/A

Methodology:

HPLC Tandem Mass Spectrometry

References:

Levine LS and Pang S (1994) “Prenatal Diagnosis and Treatment of Congenital Adrenal Hyperplasia,” J Pediatr Endocrinol, 7(3): 193-200

Forest MG, David M and Morel Y (1993) “Prenatal Diagnosis and Treatment of 21-Hydroxylase Deficiency,” J Steroid Biochem Mol Biol,45(1-3):75-82

Esoterix, Inc Web Page April 2012

Esoterix, Inc. “Expected Value and S.I. Unit Conversion Table” Fifth Edition

Updates:

4/17/2012: Updated reference ranges.



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