Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

PROCAINAMIDE AND NAPA LEVELS

General Information

Lab Order Codes:

PRNP, PRNM (Stat to MedTox)

Synonyms:

n-acetylprocainamide, PronestylŪ, Procan-SrŪ

CPT Codes:

80192 – Procainamide; with metabolites (NAPA)

Test Includes:

Procainamide, n-acetylprocainamide, and procainamide/n-acetylprocainamide combined levels all reported in mcg/mL.

Logistics

Test Indications:

Monitoring therapy, assessing compliance, evaluating toxicity. Procainamide is indicated in the treatment of premature ventricular contractions, ventricular tachycardia, atrial defibrillation, and paroxysmal atrial tachycardia.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (Test: PA), MedTox (Test# 104) - Stat only

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 day; test set up daily

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.2 mL) blood

Processed Volume:

1 mL (Minimum 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Gross hemolysis, mislabeled or unlabeled specimens

Interpretive

Reference Range:

Test:

Mayo Reference values (mcg/mL):

MedTox Reference values (mcg/mL):

Procainamide:

4.0 – 8.0 mcg/mL

4.0 - 8.0 mcg/mL

NAPA (n-acetylprocainamide):

4.0 – 8.0 mcg/mL

12.0 - 25.0 mcg/mL

Procainamide and NAPA:

Not listed

Not listed

Critical Values:

Procainamide:

>10.0 mcg/mL

≥12.0 mcg/mL

Procainamide and NAPA:

Not listed

≥30.0 mcg/mL

NAPA (n-acetylprocainamide):

>40.0 mcg/mL

Not listed

Limitations:

Procainamide:

Not listed

Reporting limit: 0.1 mcg/mL

NAPA:

Not listed

Reporting limit: 0.6 mcg/mL

Methodology:

Immunoassay, includes a separate determination for NAPA

References:

Mayo Medical Laboratories Web Page October 2012
Medtox Laboratories
October 2009

Updates:

10/27/2009: Plasma samples are no longer accepted.
10/25/2012: Updated reference ranges and critical values at MML.



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