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Lab Dept:
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Chemistry
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Test Name:
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PROCAINAMIDE AND NAPA LEVELS
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General Information
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Lab Order Codes:
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PRNP, PRNM (Stat to MedTox)
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Synonyms:
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n-acetylprocainamide, PronestylŪ, Procan-SrŪ
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CPT Codes:
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80192 – Procainamide; with metabolites (NAPA)
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Test Includes:
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Procainamide, n-acetylprocainamide, and procainamide/n-acetylprocainamide combined levels all reported in mcg/mL.
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Logistics
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Test Indications:
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Monitoring therapy, assessing compliance, evaluating toxicity. Procainamide is indicated in the treatment of premature ventricular contractions, ventricular tachycardia, atrial defibrillation, and paroxysmal atrial tachycardia.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test: PA), MedTox (Test# 104) - Stat only
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 day; test set up daily
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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3 mL (Minimum: 1.2 mL) blood
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Processed Volume:
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1 mL (Minimum 0.4 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Gross hemolysis, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Test:
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Mayo Reference values (mcg/mL):
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MedTox Reference values (mcg/mL):
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Procainamide:
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4.0 – 8.0 mcg/mL
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4.0 - 8.0 mcg/mL
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NAPA (n-acetylprocainamide):
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4.0 – 8.0 mcg/mL
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12.0 - 25.0 mcg/mL
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Procainamide and NAPA:
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Not listed
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Not listed
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Critical Values:
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Procainamide:
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>10.0 mcg/mL
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≥12.0 mcg/mL
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Procainamide and NAPA:
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Not listed
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≥30.0 mcg/mL
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NAPA (n-acetylprocainamide):
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>40.0 mcg/mL
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Not listed
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Limitations:
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Procainamide:
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Not listed
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Reporting limit: 0.1 mcg/mL
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NAPA:
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Not listed
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Reporting limit: 0.6 mcg/mL
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Methodology:
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Immunoassay, includes a separate determination for NAPA
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References:
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Mayo Medical Laboratories Web Page October 2012
Medtox Laboratories October 2009
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Updates:
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10/27/2009: Plasma samples are no longer accepted.
10/25/2012: Updated reference ranges and critical values at MML.
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