|
|
Lab Dept:
|
Chemistry
|
Test Name:
|
PROZAC LEVEL
|
General Information
|
Lab Order Codes:
|
PZAC
|
Synonyms:
|
Fluoxetine; Norfluoxetine; SarafemŽ
|
CPT Codes:
|
82542 - Column chromatography/mass spectrometry, analyte not elsewhere specified; quantitative, single stationary and mobile phase
|
Test Includes:
|
Fluoxetine and Norfluoxetine reported in ng/mL.
|
Logistics
|
Test Indications:
|
Antidepressant therapeutic drug monitoring.
|
Lab Testing Sections:
|
Chemistry - Sendouts
|
Referred to:
|
MedTox Laboratories (Test# 225)
|
Phone Numbers:
Minneapolis:
Saint Paul:
|
|
612-813-6280
|
651-220-6550
|
Test Availability:
|
Daily, 24 hours
|
Turnaround Time:
|
1 day
|
Special Instructions:
|
Trough levels are most reproducible. Do Not use serum separator tubes.
|
Specimen
|
Specimen Type:
|
blood
|
Container:
|
Green top (Li Heparin) or Red top (plain, no gel) tube
|
Draw Volume:
|
6 mL (Minimum: 1.2 mL) blood
|
Processed Volume:
|
2 mL (Minimum 0.4 mL) plasma/serum
Note: Submission of the minimum volume results in an elevated reporting limit and inability to repeat analysis.
|
Collection:
|
Routine venipuncture
|
Special Processing:
|
Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
|
Patient Preparation:
|
None
|
Sample Rejection:
|
Mislabeled or unlabeled specimens
|
Interpretive
|
Reference Range:
|
Fluoxetine and metabolite:
300 – 1150 ng/mL
|
Critical Values:
|
>2000 ng/mL
|
Limitations:
|
<10 ng/mL reporting limit
|
Methodology:
|
High Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV)
|
References:
|
MedTox Laboratories May 2010
|
Updates:
|
5/6/2010: CPT update, previously reported as 82492.
|
