Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

TEGRETOL EPOXIDE LEVEL

General Information

Lab Order Codes:

EPOX

Synonyms:

Carbamazepine-10,11-Epoxide, Tegretol®, Epoxide, CB2

CPT Codes:

80156 – Carbamezepine, total
82491 - Chromatography, quantitative, column; single analyte not elsewhere specified, single stationary and mobile phase

Test Includes:

Carbamazepine and Carbamazepine-10,11 Epoxide levels reported in ug/mL.

Logistics

Test Indications:

Antiepileptic (Anticonvulsant) therapeutic drug monitoring

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (MedTox Test: 150)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 day

Special Instructions:

Trough levels are most reproducible.

Specimen

Specimen Type:

Whole blood

Container:

Green top (Li Heparin) or Red top tube

Draw Volume:

6 mL (Minimum: 0.5 mL) blood

Processed Volume:

2 mL (Minimum: 0.2 mL) serum/plasma

Note: Submission of the minimum volume results in an elevated reporting limit and inability to repeat analysis.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patµient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Carbamazepine:

4.0 – 12.0 ug/mL

Carbamazepine-10,11-Epoxide:

0.4 – 4.0 ug/mL

Critical Values:

Carbamazepine:

>15.0 ug/mL

Carbamazepine-10,11-Epoxide:

>7.0 ug/mL

Limitations:

Carbamazepine:

0.7 ug/mL reporting limit

Carbamazepine 10, 11-Expoxide:

0.2 ug/mL reporting limit

Methodology:

High Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV)

References:

MedTox Laboratories July 2006



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