Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

MEXILETINE LEVEL

General Information

Lab Order Codes:

MEX

Synonyms:

Mexitil®

CPT Codes:

80299 – Quantitation of drug, not elsewhere specified

Test Includes:

Mexiletine concentration measured in mcg/mL.

Logistics

Test Indications:

Useful for assessing achievement of optimal therapeutic concentrations and assessing potential toxicity.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 9245/MEX)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 8 days, batched and performed once weekly

Special Instructions:

See Patient Preparation

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

9 mL (Minimum: 3.3 mL) blood

Processed Volume:

3 mL (Minimum: 1.1 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom vial. Note whether specimen is serum. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

Draw blood after patient has been receiving mexiletine for at least 3 days and just before administration of the next dose.

Sample Rejection:

Gross hemolysis; gross lipemia; grossly icteric; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Therapeutic range: 0.80 – 2.0 mcg/mL (trough value)

Critical Values:

Toxic concentration: >2.0 mcg/mL (trough value)

Limitations:

N/A

Methodology:

High Performance Liquid Chromatography (HPLC)

References:

Mayo Medical Laboratory Web Page January 2013

Updates:

12/12/2011: Plasma is no longer an acceptable specimen type. Units update from ug/mL to mcg/mL.



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