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Lab Dept:
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Chemistry
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Test Name:
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MEXILETINE LEVEL
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General Information
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Lab Order Codes:
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MEX
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Synonyms:
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Mexitil®
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CPT Codes:
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80299 – Quantitation of drug, not elsewhere specified
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Test Includes:
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Mexiletine concentration measured in mcg/mL.
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Logistics
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Test Indications:
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Useful for assessing achievement of optimal therapeutic concentrations and assessing potential toxicity.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 9245/MEX)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 8 days, batched and performed once weekly
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Special Instructions:
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See Patient Preparation
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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9 mL (Minimum: 3.3 mL) blood
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Processed Volume:
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3 mL (Minimum: 1.1 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom vial. Note whether specimen is serum. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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Draw blood after patient has been receiving mexiletine for at least 3 days and just before administration of the next dose.
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Sample Rejection:
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Gross hemolysis; gross lipemia; grossly icteric; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Therapeutic range: 0.80 – 2.0 mcg/mL (trough value)
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Critical Values:
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Toxic concentration: >2.0 mcg/mL (trough value)
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Limitations:
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N/A
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Methodology:
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High Performance Liquid Chromatography (HPLC)
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References:
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Mayo Medical Laboratory Web Page January 2013
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Updates:
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12/12/2011: Plasma is no longer an acceptable specimen type. Units update from ug/mL to mcg/mL.
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