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Lab Dept:

Chemistry

Test Name:

PYRUVATE KINASE, RBC

General Information

Lab Order Codes:

PYKI

Synonyms:

Pyruvate Kinase, Erythrocytes

CPT Codes:

84220 – Pyruvate kinase

Test Includes:

Pyruvate kinase RBC level reported in U/g Hb.

Logistics

Test Indications:

Useful for the workup of cases of nonspherocytic hemolytic anemia, for a family workup to determine inheritance pattern (pyruvate kinase deficiency is autosomal recessive), and for genetic counseling.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8659/PK)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 4 days, test set up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Whole blood

Container:

Yellow top (ACD- Solution B) tube

Draw Volume:

4 mL (Minimum: 1 mL) blood

Processed Volume:

Same as Draw Volume – Do Not process

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Do Not centrifuge. Send whole blood refrigerated in original collection container. Do Not transfer blood to other containers. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimen cannot be frozen; mislabeled or unlabeled specimens

Interpretive

Reference Range:

6.7 – 14.3 U/g Hb

Critical Values:

N/A

Limitations:

Because leukocytes also contain pyruvate kinase that is not diminished in hereditary erythrocytic pyruvate kinase deficiency, freeing the blood of white blood cells is always critical to this test.

Methodology:

Kinetic Spectrophotometry (KS)

References:

Mayo Medical Laboratories October 2014

Updates:

8/31/2010: Units and reference range update.



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