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Lab Dept:
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Chemistry
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Test Name:
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COPPER, SERUM
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General Information
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Lab Order Codes:
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COPP
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Synonyms:
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Cu, blood
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CPT Codes:
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82525 - Copper
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Test Includes:
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Copper level reported in mcg/mL.
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Logistics
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Test Indications:
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Useful for diagnosis of Wilson’s disease, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
In normal serum, more than 95% of the copper is incorporated into the enzyme, ceruloplasmin; the remaining copper is loosely bound to albumin. A deficiency in copper results in severe derangement in growth and metabolism and impairment of erythropoiesis.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 8612)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test set-up Monday - Saturday
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Special Instructions:
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See Container and Collection and Patient Preparation for special requirements.
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Specimen
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Specimen Type:
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Blood
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Container:
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Metal free syringe and Royal Blue top (Trace element tube)
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Draw Volume:
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2.4 mL (Minimum: 1.0 mL) blood
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Processed Volume:
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0.8 mL (Minimum: 0.2 mL) serum
Note: Submission of the minimum volume does not allow repeat analysis.
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Collection:
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Use stainless steel needle or butterfly vacutainer collection. Collect in a royal blue top tube (See Container). Avoid hemolysis.
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Special Processing:
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Lab Staff: Blood specimens for serum testing should be collected in the royal blue-top Monoject® Trace Element Blood Collection Tube.
1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction within 4 hours of specimen collection.
2. Remove the stopper and carefully pour 0.4 mL serum into a 7.0 mL, Mayo metal free, screw-capped, polypropylene vial (Mayo Supply T173), avoiding transfer of the cellular components of blood. Do Not insert a pipet into the serum to accomplish transfer, and Do Not ream the specimen with a wooden stick to assist with serum transfer.
3. Place the cap on the polypropylene vial tightly, attach a specimen label and send specimen to the laboratory at refrigerated or frozen temperature.
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Patient Preparation:
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Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered, a specimen cannot be collected for 48 hours
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Sample Rejection:
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Specimens other than serum, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Age:
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Reference Range (mcg/mL)
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0 – 2 mos.
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0.40 – 1.40 mcg/mL
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3 – 6 mos.
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0.40 – 1.60 mcg/mL
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7 – 9 mos.
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0.40 – 1.70 mcg/mL
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10 – 12 mos.
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0.80 – 1.70 mcg/mL
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13 mos. – 10 yrs.
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0.80 – 1.80 mcg/mL
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≥11 yrs.
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0.75 – 1.45 mcg/mL
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Critical Values:
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N/A
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Limitations:
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Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered, a specimen cannot be collected for 48 hours.
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Methodology:
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Dynamic Reaction Cell DRC) II Inductively Coupled Plasma Mass Spectrophotometry (DRC-ICP-MS)
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References:
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Mayo Medical Laboratories Web Page (April 2010)
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Updates:
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11/11/2008: Reference range previously reported as 0.75 - 1.45 µg/mL for all ages. New reference ranges have now been established for pediatrics.
4/6/2010: Method change; previously listed as Inductively Coupled Plasma (ICP) Emission Spectroscopy
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