Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

DESIPRAMINE LEVEL

General Information

Lab Order Codes:

DSP

Synonyms:

Norpramin®; Tricyclic Antidepressants; TCA

CPT Codes:

80160 - Desipramine

Test Includes:

Desipramine level reported in ng/mL.

Logistics

Test Indications:

Desipramine is used for relief of symptoms of endogenous depression, requiring 1-3 weeks of treatment before therapeutic effectiveness becomes apparent.

Lab Testing Sections:

Chemistry – Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 81854/DESIP)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 - 4 days

Special Instructions:

Do Not use separator tubes for collection.

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

6 - 9 mL blood

Processed Volume:

2 – 3 mL (Minimum: 1.1 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, serum must be separated within 2 hours of collection, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Therapeutic: 100 - 300 ng/mL

Note: Therapeutic ranges are for samples drawn at trough (i.e., immediately before next scheduled dose). Levels may be elevated in non-trough samples.

Critical Values:

Toxic: ≥500 ng/mL

Limitations:

This test cannot be performed on whole blood. Plasma must be separated from cells within 2 hours of drawing. If serum is received, SST tubes are not acceptable.

Methodology:

High Performance Liquid Chromatography (HPLC)

References:

Mayo Medical Laboratory Web Page (October 2009)

Updates:

3/25/2004: Test moved from MedTox Laboratories to Mayo Medical Laboratories.
10/27/2009: Note: Updated reference ranges. Plasma samples are no longer accepted.



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