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Lab Dept:
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Chemistry
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Test Name:
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DESIPRAMINE LEVEL
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General Information
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Lab Order Codes:
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DSP
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Synonyms:
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Norpramin®; Tricyclic Antidepressants; TCA
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CPT Codes:
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80160 - Desipramine
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Test Includes:
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Desipramine level reported in ng/mL.
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Logistics
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Test Indications:
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Desipramine is used for relief of symptoms of endogenous depression, requiring 1-3 weeks of treatment before therapeutic effectiveness becomes apparent.
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Lab Testing Sections:
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Chemistry – Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 81854)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 - 4 days
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Special Instructions:
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Do Not use separator tubes for collection.
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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6 - 9 mL blood
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Processed Volume:
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2 – 3 mL (Minimum: 1.1 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, serum must be separated within 2 hours of collection, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Therapeutic: 100 - 300 ng/mL
Note: Therapeutic ranges are for samples drawn at trough (i.e., immediately before next scheduled dose). Levels may be elevated in non-trough samples.
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Critical Values:
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Toxic: ≥500 ng/mL
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Limitations:
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This test cannot be performed on whole blood. Plasma must be separated from cells within 2 hours of drawing. If serum is received, SST tubes are not acceptable.
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Methodology:
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High Performance Liquid Chromatography (HPLC)
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References:
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Mayo Medical Laboratory Web Page (October 2009)
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Updates:
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3/25/2004: Test moved from MedTox Laboratories to Mayo Medical Laboratories.
10/27/2009: Note: Updated reference ranges. Plasma samples are no longer accepted.
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