Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

CLOMIPRAMINE LEVEL

General Information

Lab Order Codes:

CLOM

Synonyms:

Anafranil®; Desmethylclomipramine

CPT Codes:

82542 – Column chromatography quant single stationary and mobile phase

Test Includes:

Clomipramine and Desmethylclomipramine concentration measured in ng/mL.

Logistics

Test Indications:

Useful for determining whether a poor therapeutic response is attributable to noncompliance. Monitoring serum concentration of clomipramine and norclomipramine to assist in optimizing the administered dose.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (MedTox Test: 890)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 4 days

Special Instructions:

Serum Separator tubes are not recommended.

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube or Green top (Lithium heparin) tube

Draw Volume:

6 mL (Miniumum: 0.6 mL) blood

Processed Volume:

2 mL (Minimum: 0.2 mL) serum/plasma

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Clomipramine:

70 – 200 ng/mL

Desmethylclomipramine:

150 – 300 ng/mL

Critical Values:

Clomipramine:

Critical high: 400 ng/mL

Desmethylclomipramine:

Critical high: 600 ng/mL

Limitations:

Trough levels are most reproducible.

Methodology:

Liquid chromatography/Tandem Mass Spectrometry (LC/MS/MS)

References:

MedTox Laboratories (March 2012)

Updates:

4/22/2004: Test moved from MedTox Laboratories to Mayo Medical Laboratories.
10/11/04: CPT change from 82491 to 80299. Minimum volume changed from 1.2 to 1.1 mL.
3/14/2012: Test moved from Mayo Medical Laboratories to MedTox. Note ref range, CPT and method changes.



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