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Lab Dept:
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Chemistry
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Test Name:
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CLOMIPRAMINE LEVEL
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General Information
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Lab Order Codes:
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CLOM
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Synonyms:
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Anafranil®; Desmethylclomipramine
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CPT Codes:
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82542 – Column chromatography quant single stationary and mobile phase
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Test Includes:
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Clomipramine and Desmethylclomipramine concentration measured in ng/mL.
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Logistics
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Test Indications:
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Useful for determining whether a poor therapeutic response is attributable to noncompliance. Monitoring serum concentration of clomipramine and norclomipramine to assist in optimizing the administered dose.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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MedTox Laboratories (Test#: 890)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 4 days
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Special Instructions:
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Serum Separator tubes are not recommended.
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top (plain, no gel) tube or Green top (Lithium heparin) tube
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Draw Volume:
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6 mL (Miniumum: 0.6 mL) blood
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Processed Volume:
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2 mL (Minimum: 0.2 mL) serum/plasma
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Clomipramine:
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70 – 200 ng/mL
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Desmethylclomipramine:
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150 – 300 ng/mL
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Critical Values:
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Clomipramine:
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Critical high: 400 ng/mL
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Desmethylclomipramine:
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Critical high: 600 ng/mL
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Limitations:
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Trough levels are most reproducible.
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Methodology:
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Liquid chromatography/Tandem Mass Spectrometry (LC/MS/MS)
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References:
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MedTox Laboratories (March 2012)
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Updates:
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4/22/2004: Test moved from MedTox Laboratories to Mayo Medical Laboratories.
10/11/04: CPT change from 82491 to 80299. Minimum volume changed from 1.2 to 1.1 mL.
3/14/2012: Test moved from Mayo Medical Laboratories to MedTox. Note ref range, CPT and method changes.
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