Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

INTERLEUKIN-2 RECEPTOR

General Information

Lab Order Codes:

IL2R

Synonyms:

IL 2 Receptor, Soluble (CD25)

CPT Codes:

83520 – Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified

Test Includes:

Interleukin-2 Receptor level reported in pg/mL.

Logistics

Test Indications:

Clinical conditions in which elevated soluble IL-2R levels are detected include AIDS, autoimmune disease, sarcoidosis, and a variety of leukemias and lymphomas. In HIV positive individuals, IL-2R is elevated during the asymptomatic phase as well as during persistent generalized lymphadenopathy and symptomatic phases. IL-2R detection may be useful in measuring T cell activation and monitoring HIV pathogenesis. Elevated IL-2R levels have clinical and prognostic significance in patients with malignant lymphoma, non-Hodgkin’s lymphoma, B cell and undifferentiated lymphomas.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories forward to ARUP (MML Test: FIL2S), (ARUP Test: 0051529)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 4 days; set-up Monday, Wednesday and Friday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Green top (Lithium Heparin) tube
Alternate tubes: Red top tube

Draw Volume:

3 mL (Minimum: 1 mL) blood

Processed Volume:

1 mL (Minimum: 0.3 mL) serum/plasma

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen and separate serum/plasma within 2 hours of collection; aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens; refrigerated specimens; contaminated or heat-inactivated specimens

Interpretive

Reference Range:

< or =1032 pg/mL

Critical Values:

N/A

Limitations:

Results are to be used for research purposes or in attempts to understand the pathophysiology of immune, infectious or inflammatory conditions.

Methodology:

Quantitative Multiplex Bead Assay

References:

Mayo Medical Laboratories Web Page February 2014

ARUP Laboratories February 2014

Updates:

3/18/2004: Test moved from Specialty Laboratories to Mayo Medical Laboratories forward to Focus Technologies. Note changes in CPT code, Methodology, and reference range.
9/16/2008: CPT update, previously reported at 83520
12/16/2013: MML now forwards to ARUP. Note change in CPT (previously 84238), method and reference ranges.
2/19/2014: Ref range update, previously listed as 0-1033 pg/mL.



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