Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

MANGANESE

General Information

Lab Order Codes:

MANG

Synonyms:

Mn

CPT Codes:

83785 - Manganese

Test Includes:

Manganese level reported in ng/mL.

Logistics

Test Indications:

Useful in detecting toxic manganese exposure or for nutritional monitoring.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8413/MNS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 6 days, test setup Tuesday and Friday

Special Instructions:

Special collection tube required. See Container below.

Specimen

Specimen Type:

Blood

Container:

Royal blue top, trace element tube (available from laboratory)

Draw Volume:

4.8 mL (Minimum: 1.2 mL) blood

Processed Volume:

1.6 mL (Minimum: 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: It is important to follow Mayo’s processing instructions for this testing to avoid contamination.

1. Allow the specimen to clot for 30 minutes, then centrifuge to separate the serum from the cellular portion of the sample.

2. Remove the stopper and carefully pour serum into a 7 mL Mayo metal-free, screw-capped plastic vial, avoiding transfer of cellular components or blood. Do Not insert a pipet into the serum to accomplish transfer and Do Not ream the specimen with a wooden stick to assist with serum transfer.

3. Send specimen refrigerated. All specimens to be stored more than 48 hours should be sent frozen.

4. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum, gross hemolysis; grossly icteric; unlabeled or mislabeled specimens

Interpretive

Reference Range:

Age

Range

0 – 15 years

Not established

> or = 16 years

0.6 – 2.3 ng/mL

Critical Values:

N/A

Limitations:

Specimens collected from healthy, unexposed adults have extremely low levels of manganese. Because of the high environmental concentration of manganese, contamination is always a possibility when considering elevated results. Precautions must be taken to ensure the specimen is not contaminated. Metal-free serum collection procedures must be followed and centrifuged serum must be aliquoted into an acid-washed Mayo metal-free vial.

High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadoliunium or iodine containing contrast media has been administered, a specimen should not be collected for 96 hours.

Methodology:

Dynamic Reaction Cell/Inductively Coupled Plasma/Mass Spectrometry (DRC-ICP-MS)

References:

Mayo Medical Laboratories February 2011

Updates:

11/28/2005: Method previously listed as Graphite Furnace Atomic Absorption Spectrometry.
2/22/2011: Updated reference ranges and specimen volumes.



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