Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

CERULOPLASMIN

General Information

Lab Order Codes:

CERP

Synonyms:

Copper Oxidase; Ferroxidase; Kayser-Fleischer Ring; Wilson’s Disease

CPT Codes:

82390 - Ceruloplasmin

Test Includes:

Ceruloplasmin level reported in mg/dL.

Logistics

Test Indications:

Investigation of patients with possible Wilson's disease.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: CERE/8364)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test set up Monday - Saturday

Special Instructions:

See Patient Preparation

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Note: Submission of the minimum volume will not allow for repeat analysis and could result in a QNS (quantity not sufficient) result.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

Fasting patient (4 hours) is recommended. Non-fasting specimens will be run if submitted.

Sample Rejection:

Gross hemolysis; gross lipemia; grossly icteric; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Age:

Males:

Females:

0 - 17 years

14.0 - 41.0 mg/dL

14.0 - 41.0 mg/dL

> or = 18 years

15.0 – 30.0 mg/dL

16.0 - 45.0 mg/dL

Interpretation: Values >14 mg/dL are expected in Wilson's disease. Values vary consistently from patient-to-patient and may be in the normal range in some patients with Wilson's disease (indicating a different primary defect).

Critical Values:

N/A

Limitations:

Ceruloplasmin levels are affected by infections (ceruloplasmin is a late acute phase reactant) and liver function.

Birth control pills and pregnancy increase ceruloplasmin levels.

Ceruloplasmin levels are not always low in patients with Wilson’s disease.

Methodology:

Immunoturbimetric

References:

Mayo Medical Laboratories Web Page March 2013

Updates:

9/23/2008: Reference range changes due to method change from colorimetric to immunoturbimetric.
11/22/2010: Reference range update due to restandardization of the assay by the kit manufacturer.
1/9/2012: Specimen storage temperature changed from frozen to refrigerated.



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