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Lab Dept:
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Chemistry
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Test Name:
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CERULOPLASMIN
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General Information
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Lab Order Codes:
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CERP
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Synonyms:
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Copper Oxidase; Ferroxidase; Kayser-Fleischer Ring; Wilson’s Disease
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CPT Codes:
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82390 - Ceruloplasmin
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Test Includes:
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Ceruloplasmin level reported in mg/dL.
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Logistics
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Test Indications:
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Investigation of patients with possible Wilson's disease.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test: CERE/8364)
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Phone Numbers:
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MIN Lab: 612-813-6280
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STP Lab: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test set up Monday - Saturday
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Special Instructions:
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See Patient Preparation
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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3 mL (Minimum: 1.5 mL) blood
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Processed Volume:
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1 mL (Minimum: 0.5 mL) serum
Note: Submission of the minimum volume will not allow for repeat analysis and could result in a QNS (quantity not sufficient) result.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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Fasting patient (4 hours) is recommended. Non-fasting specimens will be run if submitted.
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Sample Rejection:
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Gross hemolysis; gross lipemia; grossly icteric; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Age:
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Males:
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Females:
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0 - 17 years
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14.0 - 41.0 mg/dL
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14.0 - 41.0 mg/dL
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> or = 18 years
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15.0 – 30.0 mg/dL
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16.0 - 45.0 mg/dL
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Interpretation: Values >14 mg/dL are expected in Wilson's disease. Values vary consistently from patient-to-patient and may be in the normal range in some patients with Wilson's disease (indicating a different primary defect).
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Critical Values:
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N/A
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Limitations:
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Ceruloplasmin levels are affected by infections (ceruloplasmin is a late acute phase reactant) and liver function.
Birth control pills and pregnancy increase ceruloplasmin levels.
Ceruloplasmin levels are not always low in patients with Wilson’s disease.
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Methodology:
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Immunoturbimetric
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References:
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Mayo Medical Laboratories Web Page March 2013
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Updates:
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9/23/2008: Reference range changes due to method change from colorimetric to immunoturbimetric.
11/22/2010: Reference range update due to restandardization of the assay by the kit manufacturer.
1/9/2012: Specimen storage temperature changed from frozen to refrigerated.
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