Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

INTERLEUKIN-6

General Information

Lab Order Codes:

IL6

Synonyms:

Interleukin-6, Highly Sensitive Elisa

CPT Codes:

83520 – Immunoassay, analyte, quantitative, not otherwise specified

Test Includes:

Interleukin 6 level reported in pg/mL.

Logistics

Test Indications:

IL-6, a multi-functional cytokine produced by a range of cells, plays a central role in host defense mechanisms, is involved in induction of B-cell differentiation, induction of IL-2 and IL-2 receptor expression and proliferation and differentiation of T cells. Elevated IL-6 concentrations are reported in a variety of autoimmune diseases (e.g., rheumatoid arthritis), proliferative diseases (e.g., mesangial proliferative glomerulonephritis), and malignancies (e.g., leukemia and lymphoma).

Lab Testing Sections:

Chemistry – Sendouts

Referred to:

Specialty Laboratories/Quest Diagnostics (SLAB Test: S51587)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 – 10 days, test is set up once weekly

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Lavender (EDTA) top tube
Alternate tube: Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Unlabeled or mislabeled specimens; thawed plasma; thawed serum; thawed serum; received room temperature; received refrigerated

Interpretive

Reference Range:

0.31 – 5.00 pg/mL

Critical Values:

N/A

Limitations:

This test was performed using a kit that has not been approved or cleared by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. This test should not be used for diagnosis without confirmation by other medically established means.

Methodology:

ELISA (Enzyme Linked Immunosorbent Immunoassay)

References:

Specialty Laboratories/Quest Web Page March 2011

Updates:

3/24/2009: Updated volumes, method and CPT.



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