|
|
Lab Dept:
|
Chemistry
|
Test Name:
|
TACROLIMUS (FK506) LEVEL
|
General Information
|
Lab Order Codes:
|
TACR
|
Synonyms:
|
FK506; Prograf®
|
CPT Codes:
|
80197 - Tacrolimus
|
Test Includes:
|
Tacrolimus concentration reported in ng/mL.
|
Logistics
|
Test Indications:
|
Useful for guiding dosage adjustments to achieve optimal immunosuppression while minimizing dose-dependant toxicity.
|
Lab Testing Sections:
|
Chemistry - Sendouts
|
Referred to:
|
Mayo Medical Laboratories (Test# 80783)
|
Phone Numbers:
Minneapolis:
Saint Paul:
|
|
612-813-6280
|
651-220-6550
|
Test Availability:
|
Daily, 24 hours
|
Turnaround Time:
|
1 - 2 days, test performed Monday - Saturday
|
Special Instructions:
|
Usual sampling time is prior to next dose for trough levels.
|
Specimen
|
Specimen Type:
|
Whole Blood
|
Container:
|
Lavender top (EDTA) tube
|
Draw Volume:
|
3.0 mL (Minimum: 1.0 mL) blood
|
Processed Volume:
|
Same as Draw Volume
|
Collection:
|
Routine venipuncture
|
Special Processing:
|
Lab Staff: Do Not centrifuge. Specimen should remain as whole blood in original collection container. Store in refrigerator. Ship at refrigerated temperatures. Forward promptly.
|
Patient Preparation:
|
None
|
Sample Rejection:
|
Mislabeled or unlabeled specimens
|
Interpretive
|
Reference Range:
|
5.0 – 15.0 ng/mL
|
Critical Values:
|
N/A
|
Limitations:
|
The recommended therapeutic range applies to trough specimens drawn just before the next dose. Blood collected at other times will yield higher results.
|
Methodology:
|
High Performance Liquid Chromatography/Tandem Mass Spectrophotometry (HPLC-MS/MS)
|
Contraindications:
|
N/A
|
References:
|
Mayo Medical Laboratory Web Page (January 2009)
|
Updates:
|
8/11/2004: Effective 8/4/2004, this test was moved from Fairview Diagnostic Laboratories to Mayo Medical Laboratories. Note: Change in Draw Volume (previously 2.0 mL), Change in Reference Range (previously 10-20 ug/L), Change in Critical Range (previously >40 ug/L) and Change in method (previously MEIA).
|
