Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

TACROLIMUS (FK506) LEVEL

General Information

Lab Order Codes:

TACR

Synonyms:

FK506; Prograf®

CPT Codes:

80197 - Tacrolimus

Test Includes:

Tacrolimus concentration reported in ng/mL.

Logistics

Test Indications:

Useful for guiding dosage adjustments to achieve optimal immunosuppression while minimizing dose-dependant toxicity.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (Test: TAKRO)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 2 days, test performed daily

Special Instructions:

Usual sampling time is prior to next dose for trough levels.

Specimen

Specimen Type:

Whole Blood

Container:

Lavender top (EDTA) tube

Draw Volume:

3 mL (Minimum: 1 mL) blood

Processed Volume:

Same as Draw Volume

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Do Not centrifuge. Specimen should remain as whole blood in original collection container. Store in refrigerator. Ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

5.0 – 15.0 ng/mL

Critical Values:

N/A

Limitations:

The recommended therapeutic range applies to trough specimens drawn just before the next dose. Blood collected at other times will yield higher results.

Methodology:

High Performance Liquid Chromatography/Tandem Mass Spectrophotometry (HPLC-MS/MS)

References:

Mayo Medical Laboratory Web Page (July 2013)

Updates:

8/11/2004: Effective 8/4/2004, this test was moved from Fairview Diagnostic Laboratories to Mayo Medical Laboratories. Note: Change in Draw Volume (previously 2.0 mL), Change in Reference Range (previously 10-20 ug/L), Change in Critical Range (previously >40 ug/L) and Change in method (previously MEIA).



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