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Lab Dept:
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Chemistry
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Test Name:
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IMMUNOREACTIVE TRYPSINOGEN, QUANTITATIVE
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General Information
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Lab Order Codes:
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IRTQ
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Synonyms:
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Immuno Trypsinogen
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CPT Codes:
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83519 - Immunoassay, analyte, quantitative; by radiopharmaceutical technique
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Test Includes:
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Immunoreactive Trypsinogen level reported in ng/mL.
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Logistics
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Test Indications:
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A sensitive test for pancreatic insufficiency, whether due to Cystic Fibrosis or other causes. Low serum IRT suggests severely impaired exocrine pancreatic function. Between 2 and 7 years of age, this test is of little diagnostic value in CF, but may be useful in other causes of pancreatic insufficiency. After age 7, this can reliably distinguish between CF patients with or without pancreatic insufficiency
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Children's Hospital, Pediatric CRC, Denver, Colorado
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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3 - 15 days, test set up weekly
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Special Instructions:
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This test is for patients ≥8 years of age.
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top (plain, no gel) tube
Alternate tube: Purple top (EDTA) tube
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Draw Volume:
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3 mL blood
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Processed Volume:
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1 mL (Minimum: 0.5 mL) serum or EDTA plasma
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship overnight Monday – Thursday at frozen temperatures. Send on dry ice. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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10 - 57 ng/mL
Patients with pancreatic insufficiency may have levels as low as 1.5 ng/mL, although levels may overlap with the normal range.
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Critical Values:
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N/A
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Limitations:
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Between 2 and 7 years of age, this test is of little diagnostic value in CF, but may be useful in other causes of pancreatic insufficiency.
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Methodology:
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Radioimmunoassay (RIA)
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References:
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Children’s Hospital, Pediatric CRC, Denver, Colorado, 2012
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