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Lab Dept:
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Chemistry
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Test Name:
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PROMETHEUS THIOPURINE METABOLITES
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General Information
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Lab Order Codes:
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P6MP
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Synonyms:
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6-thioguanine; 6-methylmercaptopurine; Thiopurine therapy; Propredict 6MP, 6TG
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CPT Codes:
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82491 x2 - Chromatography, quantitative, column; single analyte not elsewhere specified, single stationary and mobile phase
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Test Includes:
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Quantitative High Pressure Liquid Chromatography for 6-thioguanine (6-TGN).
Quantitative High Pressure Liquid Chromatography for 6-methylmercaptopurine (6-MMPN).
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Logistics
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Test Indications:
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Provides red blood cell (RBC) levels of 6-thioguanine (6-TG) and 6-methyl-mercaptopurine (6-MMP). These target levels help monitor a patient’s metabolism of azathioprine or 6-mercaptopurine and provide information regarding the “therapeutic window” on an individualized basis.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories forward to Prometheus Laboratories, Inc. (Test# 91564)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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4 - 7 days
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Lavender top (EDTA) tube
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Draw Volume:
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5.mL (Pediatric Minimum: 3.0 mL) blood
Note: Submission of the Minimum volume will not allow repeat analysis. In some situations, a Minimum specimen volume may result in a QNS result, requiring a second sample to be collected.
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Processed Volume:
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Same as Draw volume
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Refrigerate specimen until shipped. This test must be shipped cool with cold packs only. Do Not freeze. Ship Monday through Thursday only. The blood is stable for <7 days at 2-8°C.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than whole blood, frozen specimens, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Metabolite:
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Reference Range:
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6-TGN
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230 - 400
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6-MMPN
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<5700
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Serial monitoring and graph information are mailed separately.
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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High Pressure Liquid Chromatography (HPLC)
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References:
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Prometheus GI Disease Management Client Services and package insert, 2004
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Mayo Medical Laboratories Web Page (April 2010)
Prometheus April 2010
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Updates:
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3/25/2004: Test moved from a direct send to Prometheus Laboratories, Inc. to Mayo Medical Laboratories forward to Prometheus Laboratories, Inc.
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