Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

DILANTIN LEVEL

General Information

Lab Order Codes:

DIL

Synonyms:

Total Phenytoin; DPH; PHT; Cerebyx®

CPT Codes:

80185 – Phenytoin, total

Test Includes:

Dilantin/Phenytoin concentration in ug/mL

Logistics

Test Indications:

Useful for therapeutic drug monitoring (TDM). Dilantin is used in the treatment of primary or secondary generalized tonic-clonic, partial, partial-complex seizures and status epilepticus. Once absorbed, the drug is tightly bound to protein.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

Post load – Peak: 1 hour after end of infusion.
Trough level – Should be drawn just before the next dose.

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into plastic sample cup. Analyze sample immediately or store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled of unlabeled specimen

Interpretive

Reference Range:

Therapeutic concentration: 10 - 20 ug/mL

Critical Values:

>30 ug/mL

Limitations:

N/A

Methodology:

Particle enhanced turbidimetric inhibition immunoassay (PETINIA)

References:

PTN Flex® reagent cartridge insert sheet Siemens Healthcare Diagnostics Inc (2008-02-29) 717064.001 – US, Rev F

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Biorad Liquichekÿ Unassayed Chemistry Control (Human) product insert, Irvine, CA

Updates:

5/1/2005: Critical value changed, previously listed as >25 ug/mL.



  Lab Test Directory
    Chemistry
    Coagulation
    Flow/Immunology
    Hematology
    Microbiology/ Virology
    Other Fluids
    Pathology
    Serology
    Transfusion Services
    Urine/Stool

  Search Lab Test Directory
    List All Documents

  Lab Staff

  E-mail Lab Services