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Lab Dept:
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Chemistry
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Test Name:
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DILANTIN LEVEL
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General Information
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Lab Order Codes:
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DIL
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Synonyms:
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Total Phenytoin; DPH; PHT; Cerebyx®
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CPT Codes:
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80185 – Phenytoin, total
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Test Includes:
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Dilantin/Phenytoin concentration in ug/mL
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Logistics
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Test Indications:
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Useful for therapeutic drug monitoring (TDM). Dilantin is used in the treatment of primary or secondary generalized tonic-clonic, partial, partial-complex seizures and status epilepticus. Once absorbed, the drug is tightly bound to protein.
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Lab Testing Sections:
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Chemistry
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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4 hours
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Special Instructions:
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Post load – Peak: 1 hour after end of infusion.
Trough level – Should be drawn just before the next dose.
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Specimen
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Specimen Type:
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Blood
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Container:
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Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain, no gel) tube
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Draw Volume:
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0.6 mL blood
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Processed Volume:
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0.2 mL serum/plasma
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Collection:
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Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into plastic sample cup. Analyze sample immediately or store at refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled of unlabeled specimen
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Interpretive
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Reference Range:
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Therapeutic concentration: 10 - 20 ug/mL
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Critical Values:
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>30 ug/mL
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Limitations:
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N/A
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Methodology:
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Particle enhanced turbidimetric inhibition immunoassay (PETINIA)
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Contraindications:
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N/A
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References:
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PTN Flex® reagent cartridge insert sheet Siemens Healthcare Diagnostics Inc (2008-02-29) 717064.001 – US, Rev F
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Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition
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Biorad Liquichekÿ Unassayed Chemistry Control (Human) product insert, Irvine, CA
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Updates:
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5/1/2005: Critical value changed, previously listed as >25 ug/mL.
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