Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

CARBAMAZEPINE LEVEL

General Information

Lab Order Codes:

CARB

Synonyms:

TegretolŪ; CarbtrolŪ; CB2

CPT Codes:

80156–Carbamazepine; total

Test Includes:

Carbamazepine concentration (includes carbemazapine epoxide) reported in ug/mL.

Logistics

Test Indications:

Useful for therapeutic drug monitoring (TDM). Carbamazepine is used in the treatment of generalized tonic-clonic, partial-complex seizures.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into plastic sample cup. Analyze sample immediately or store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

Therapeutic concentration: 4.0 – 8.0 ug/mL

Critical Values:

Toxic concentration: >20.0 ug/mL

Limitations:

N/A

Methodology:

Particle Enhance Turbidimetric Inhibition Immunoassay (PETINIA)

References:

CRBM Flex™ reagent cartridge insert sheet Siemens Healthcare Diagnostics 2009-05-20 Rev F PN 717087.001

Clinical Significance, Dade Behring Inc., Glasgow Business Community, Mailbox 531, P.O. Box 6101, Newark, Delaware 19714

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Biorad Liquichek Unassayed Chemistry Control Product Insert, Bio-Rad Laboratories, Irvine, CA 92618

Updates:

5/1/2005: Critical range changed, previously reported as >15.0 ug/mL.



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