Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

ACETAMINOPHEN LEVEL

General Information

Lab Order Codes:

ACET

Synonyms:

Tylenol®, Datril®, Excedrin®, Liquiprin®, Tempra®

CPT Codes:

82003 - Acetaminophen

Test Includes:

Acetaminophen concentration in mcg/mL.

Logistics

Test Indications:

Useful for therapeutic drug monitoring and evaluation of acetaminophen toxicity. This commonly used analgesic drug may cause severe hepatic toxicity or death when consumed in overdose quantities.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours, Stat: 1 hour

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain or serum separator) tubes

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Ingestion: Specimen should be drawn 4 hours after ingestion for peak toxic level.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into plastic sample cup. Analyze immediately or store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

Therapeutic concentration: 10-25 mcg/mL

Critical Values:

>25 mcg/mL

Limitations:

Bilirubin (5 mg/dL), IgG (5 g/dL) and/or Total Protein (12 g/dL) decrease the acetaminophen result by 20-60%.

Methodology:

Enzymatic

References:

Siemens Dimension Vista® ACTM Flex® reagent Instructions for Use, Siemens Healthcare Diagnostics, PN 781088.001, Issue date, 2012-10-29, Rev H

Siemens Dimension ACTM® Flex reagent Instructions for Use, Siemens Healthcare Diagnostics, Newark, DE 19714, 03/06/2008, Version F

 

Siemens Dimension Vista® Drug 2 Calibrator Instructions for Use, Issue date 9/2012

 

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Updates:

2/1/2012: Critical value update.
9/10/2014: Limitations added.



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