Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

GENTAMICIN LEVEL, SERUM

General Information

Lab Order Codes:

GENT

Synonyms:

Garamycin®

CPT Codes:

80170 – Gentamicin

Test Includes:

Gentamicin concentration in ug/mL

Logistics

Test Indications:

Useful in monitoring therapeutic dosage and is affective against gram-negative bacteria.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

A peak level should be drawn 30-60 minutes after infusion. A trough level should be drawn just before the next dose

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into plastic sample cup. Store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

Peak Levels

Therapeutic concentration:

4 – 8 ug/mL

Trough Levels

Therapeutic concentration:

<2 ug/mL generally indicates elimination of the drug

Critical Values:

Toxic concentration peak: >10 ug/mL

Toxic concentration trough: >2 ug/mL for >10 days

Limitations:

Aminoglycosides similar in structure may cross-react with this assay.

Methodology:

Particle Enhanced Turbidimetric Inhibition Immunoassay (Petinia)

References:

GENT Flex™ reagent cartridge insert sheet, Siemens Healthcare Diagnostics (2008-03-03) Rev. F 717012.001 - US

Clinical Significance, Dade Behring Inc., Glasgow Business Community, Mailbox 531, P.O. Box 6101, Newark, Delaware 19714

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition, 2001

Biorad Liquichek Unassayed Chemistry Control Product Insert, Bio-Rad Laboratories, Irvine, CA 92618



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