Higher plasma homocysteine concentrations are detected in non-fasting specimens.
Factors influencing plasma homocysteine concentration levels include:
Gender: Approximately 25% higher in men vs. age-matched premenopausal women.
Age: Increases with age
Lifestyle: Smoking, lack of exercise
Diet: Cofactor deficiencies
Disease states: Psoriasis, Leukemia
Medications Influencing Plasma HCY levels:
Methotrexate: 5-methyltetrahydrofolate depletion
Azuridine: Vitamin B6 antagonist
Nitrous Oxide: Inactivation vitamin B12
Phenytoin: Interference with folate metabolism
Carbamezapine: Interference with folate metabolism
Oral contraceptives: Estrogen-induced vitamin B6 deficiency
Penicillamine: Reduction in homocysteine levels