Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

LEVETIRACETAM LEVEL

General Information

Lab Order Codes:

LEVET

Synonyms:

Keppra

CPT Codes:

83520 – Immunoassay for analyte other than infectious agent antibody or infectious antigen agent; quantitative, not otherwise specified

Test Includes:

Levetiracetam level reported in ug/mL.

Logistics

Test Indications:

This test is used for monitoring levetiracetam therapy. Because levetiracetam has a wide therapeutic index and linear dose-concentration dependence, drug monitoring is not indicated in all patients. Drug concentration monitoring can be useful in documenting failure to respond that may be due to noncompliance, or to guide dosage adjustments in patients with renal failure.

Lab Testing Sections:

Chemistry – St Paul Campus

Phone Numbers:

MIN: 612-813-6280

STP: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours, performed daily

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube, preferred [Alternate: Green (Lithium Heparin) tube]. No gel.

Draw Volume:

1.5 mL (Minimum: 0.6 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.2 mL) serum/plasma

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic sample cup. Store and ship at refrigerated temperatures.
Mpls: Forward specimen promptly to St. Paul.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Expected steady state trough concentrations in patients receiving recommended daily dosages: 5 - 45 ug/mL. Toxic range has not been established.

Critical Values:

N/A

Limitations:

Reporting limit: 2.0 ug/mL

Methodology:

Immunoassay

References:

MedTox Laboratories December 2010

Updates:

6/14/2004: Test changed from storage and shipment at ambient temperatures to refrigerated temperatures.
12/7/2010: Information updated for MedTox, Mayo information no longer referenced. All specimens to be sent to MedTox.
9/28/2012: Levetiracetam testing now performed internally at Children’s



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