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Lab Dept:
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Chemistry
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Test Name:
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DIAZEPAM AND NORDIAZEPAM LEVELS
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General Information
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Lab Order Codes:
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DINOR
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Synonyms:
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Benzodiazepines; Clorazepate Dipotassium; Tranxene; Valium
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CPT Codes:
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80154 - Benzodiazepines
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Test Includes:
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Concentrations of Diazepam, Nordiazepam and total of both reported in mcg/mL.
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Logistics
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Test Indications:
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Assessing compliance, monitoring for appropriate therapeutic level, assessing toxicity.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# 8629)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 – 9 days, performed once per week
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top (plain, no gel) tube
Note: Gel tubes are not acceptable.
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Draw Volume:
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9 mL (Minimum: 3.3 mL) blood
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Processed Volume:
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3 mL (Minimum: 1.1 mL) serum
Note: Submission of the minimum volume does not allow for repeat analysis and may result in a QNS (quantity not sufficient) test result.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Therapeutic concentrations:
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Diazepam:
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0.2 – 0.8 mcg/mL
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Nordiazepam:
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0.2 – 1.0 mcg/mL
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Total of both:
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0.4 – 1.8 mcg/mL
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This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the US Food and Drug Administration.
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Critical Values:
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Total of both: ≥5.0 mcg/mL
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Limitations:
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N/A
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Methodology:
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High-Pressure Liquid Chromatography (HPLC)
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References:
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Mayo Medical Laboratories (July 2010)
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Updates:
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4/6/2004: Test moved from MedTox Laboratories, Inc. to Mayo Medical Laboratories. Test formerly named: Tranxene.
1/13/2009: Min. volume amended.
5/4/2010: Transport temperature changed from ambient to refrigerated.
7/12/2010: Units updated from ug/mL to mcg/mL.
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