Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

DIAZEPAM AND NORDIAZEPAM LEVELS

General Information

Lab Order Codes:

DINOR

Synonyms:

Benzodiazepines; Clorazepate Dipotassium; Tranxene; Valium

CPT Codes:

80154 - Benzodiazepines

Test Includes:

Concentrations of Diazepam, Nordiazepam and total of both reported in mcg/mL.

Logistics

Test Indications:

Assessing compliance, monitoring for appropriate therapeutic level, assessing toxicity.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8629/DIA)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 – 9 days, performed once per week

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube

Note:
Gel tubes are not acceptable.

Draw Volume:

9 mL (Minimum: 3.3 mL) blood

Processed Volume:

3 mL (Minimum: 1.1 mL) serum

Note: Submission of the minimum volume does not allow for repeat analysis and may result in a QNS (quantity not sufficient) test result.

Collection:

Routine venipuncture

Special Processing:

Lab staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Therapeutic concentrations:

Diazepam:

0.2 – 0.8 mcg/mL

Nordiazepam:

0.2 – 1.0 mcg/mL

Total of both:

0.4 – 1.8 mcg/mL

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the US Food and Drug Administration.

Critical Values:

Total of both: ≥5.0 mcg/mL

Limitations:

N/A

Methodology:

High-Pressure Liquid Chromatography (HPLC)

References:

Mayo Medical Laboratories (July 2010)

Updates:

4/6/2004: Test moved from MedTox Laboratories, Inc. to Mayo Medical Laboratories. Test formerly named: Tranxene.
1/13/2009: Min. volume amended.
5/4/2010: Transport temperature changed from ambient to refrigerated.
7/12/2010: Units updated from ug/mL to mcg/mL.



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