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Lab Dept:
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Chemistry
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Test Name:
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VALPROIC ACID LEVEL
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General Information
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Lab Order Codes:
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VALP
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Synonyms:
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Depakene; Depakane, Depakote; Dipropylacetic acid; VPA; Divalproex; Valproate
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CPT Codes:
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80164 – Dipropylacetic acid (valproic acid)
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Test Includes:
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Valproic acid concentration reported in ug/mL.
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Logistics
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Test Indications:
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Valproic acid is used for treatment of seizures. Valproic acid may be used in conjunction with other antiepileptics against tonic-clonic and partial seizures. Peak levels are reached in 1-4 hours. The biologic half-life is about 15 hours.
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Lab Testing Sections:
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Chemistry
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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4 hours
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Green top (Li Heparin) tube preferred
Alternate tube: Red-top (plain, no gel) tube
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Draw Volume:
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0.6 mL blood
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Processed Volume:
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0.2 mL plasma/serum
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Collection:
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Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a plastic sample cup. Store at refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimen; specimens other than heparinized plasma or serum
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Interpretive
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Reference Range:
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Therapeutic concentration: 50-100 ug/mL
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Critical Values:
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Toxic concentration: >200 ug/mL
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Limitations:
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N/A
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Methodology:
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Particle Enhanced Turbidimetric Inhibition Immunoassy (PETINIA)
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References:
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VALP Flex® reagent cartridge insert sheet, Siemens Healthcare Diagnostics Inc, 2008-02-29 717078.001 – US, Rev E
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www.childrensmn.org/Lexi-Comp Copyright © 1978-2006 Lexi-Comp Inc
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Clinical Significance, Dade Behring Inc., Glasgow Business Community, Mailbox 531, P.O. Box 6101, Newark, Delaware 19714
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Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition
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Biorad Liquichek Unassayed Chemistry Control Product Insert, Bio-Rad Laboratories, Irvine, CA 92618
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Updates:
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5/1/2005: Critical value changed, previously listed as >150 ug/mL.
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