Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

VALPROIC ACID LEVEL

General Information

Lab Order Codes:

VALP

Synonyms:

Depakene; Depakane, Depakote; Dipropylacetic acid; VPA; Divalproex; Valproate

CPT Codes:

80164 – Dipropylacetic acid (valproic acid)

Test Includes:

Valproic acid concentration reported in ug/mL.

Logistics

Test Indications:

Valproic acid is used for treatment of seizures. Valproic acid may be used in conjunction with other antiepileptics against tonic-clonic and partial seizures. Peak levels are reached in 1-4 hours. The biologic half-life is about 15 hours.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red-top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL plasma/serum

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a plastic sample cup. Store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen; specimens other than heparinized plasma or serum

Interpretive

Reference Range:

Therapeutic concentration: 50-100 ug/mL

Critical Values:

Toxic concentration: >200 ug/mL

Limitations:

N/A

Methodology:

Particle Enhanced Turbidimetric Inhibition Immunoassy (PETINIA)

References:

VALP Flex® reagent cartridge insert sheet, Siemens Healthcare Diagnostics Inc, 2008-02-29 717078.001 – US, Rev E

www.childrensmn.org/Lexi-Comp Copyright © 1978-2006 Lexi-Comp Inc

Clinical Significance, Dade Behring Inc., Glasgow Business Community, Mailbox 531, P.O. Box 6101, Newark, Delaware 19714

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Biorad Liquichek Unassayed Chemistry Control Product Insert, Bio-Rad Laboratories, Irvine, CA 92618

Updates:

5/1/2005: Critical value changed, previously listed as >150 ug/mL.



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