Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

PHENOBARBITAL LEVEL

General Information

Lab Order Codes:

PHB

Synonyms:

Luminal, PHB

CPT Codes:

80184 - Phenobarbital

Test Includes:

Phenobarbital concentration reported in ug/mL.

Logistics

Test Indications:

Useful for therapeutic drug monitoring (TDM). Phenobarbital is used in the treatment of seizures. It is particularly useful for treatment of generalized tonic-clonic, partial, focal motor, temporal lobe and febrile seizures.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

Peak concentrations are reached several hours after a single large dose. The half-life ranges from 53 to 140 hours.

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a plastic sample cup. Store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

Therapeutic concentration: 15 - 40 ug/mL

Critical Values:

>60 ug/mL

Limitations:

N/A

Methodology:

Particle Enhanced Turbidimetric Inhibition Immunoassay (PETINIA)

References:

PHNO Flex® reagent cartridge insert sheet Siemens Healthcare Diagnostics Inc (2008-02-20) 717060.002 – US, Rev H

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Biorad LiquichekÔ Unassayed Chemistry Control (Human) product inser, Irvine, CA

Updates:

5/1/2005: Critical value changed, previously listed as >50 ug/mL.



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