Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

C4 (FOURTH COMPONENT OF COMPLEMENT)

General Information

Lab Order Codes:

C4

Synonyms:

C’4; Fourth component of complement; Complement 4

CPT Codes:

86160 – Complement; antigen, each component

Test Includes:

C4 concentration reported in mg/dL.

Logistics

Test Indications:

C4 is essential for the activation of the classical pathway. C4 deficiency is associated with very high prevalence of autoimmune or collagen vascular disease. It has been proposed that C4 may be critical for the clearance of viral infections.

Lab Testing Sections:

Chemistry (all testing is performed on the Mpls campus)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 4 days, testing performed Tuesday, Wednesday and Friday.

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic sample cup. Specimens can be stored at refrigerated temperatures for up to eight days. Centrifuge turbid or particulate samples prior to analysis.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens; specimens other than serum; lipemic or turbid specimens

Interpretive

Reference Range:

10 - 40 mg/dL

Critical Values:

N/A

Limitations:

N/A

Methodology:

Nephelometry BN Prospec

References:

Herbert, L. E. et al (1991) Kidney International; 39: 811

West, C D (1989) Complement Inflamm; 6: 4

Dalmasso, P (1986) Critical Reviews in Clinical Laboratory Sciences; 4: 123

Okumura, N. et al., Clinical Laboratory Science 1990; 3: 54

Baudner, S. et al., J. Lab. Med. 1996; 20: 145

Tietz, NW, Textbook of Clinical Chemistry (1986) WB Saunders Co., Philadelphia, PA, pp 52-53 (techniques and procedures to minimize laboratory infections) and pp 478-497 (specimen collection and storage recommendations).

N Antisera to Human Complement Factors (C3c, C4) Package Insert (May 2008) Siemens Healthcare Diagnostics, Newark, DE

N Protein Standard SL Package Insert (May 2008) Siemens Healthcare Diagnostics, Newark



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