|
|
|
|
|
|
|
Lab Dept:
|
Chemistry
|
Test Name:
|
IGG SUBCLASSES
|
General Information
|
Lab Order Codes:
|
IGS
|
Synonyms:
|
Immunoglobulin G Subclasses
|
CPT Codes:
|
82784 – Gammaglobulin; IgG
82787 – Gammaglobulin; immunoglobulin subclasses
|
Test Includes:
|
Total IgG concentration and IgG subclass 1-4 concentrations reported in mg/dL.
|
Logistics
|
Test Indications:
|
Immunoglobulins, also known as humoral antibodies, recognize antigens and initiate mechanisms that destroy antigens. Its major function appears to be neutralization of toxins (bacterial or viral), in tissue spaces. IgG has four subclasses that are slightly different in structure of their variable regions and in electrophoretic mobility.
|
Lab Testing Sections:
|
Chemistry (all specimens analyzed on the Mpls campus)
|
Phone Numbers:
Minneapolis:
Saint Paul:
|
|
612-813-6280
|
651-220-6550
|
Test Availability:
|
Daily, 24 hours
|
Turnaround Time:
|
1 – 4 days, testing performed Tuesday, Wednesday and Friday.
|
Special Instructions:
|
N/A
|
Specimen
|
Specimen Type:
|
Blood
|
Container:
|
Red top (plain, no gel) tube
|
Draw Volume:
|
1.5 mL blood
|
Processed Volume:
|
0.5 mL serum
|
Collection:
|
Routine venipuncture
|
Special Processing:
|
Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic sample cup. Specimens can be stored at refrigerated temperatures. Centrifuge turbid or particulate samples prior to analysis.
|
Patient Preparation:
|
None
|
Sample Rejection:
|
Mislabeled or unlabeled specimen; specimens other than serum; turbid samples that do not clear after centrifugation
|
Interpretive
|
Reference Range:
|
IgG Total
|
Age:
|
Range mg/dL:
|
Newborn:
|
611 - 1542 mg/dL
|
1 month:
|
241 - 870 mg/dL
|
2 months:
|
198 - 577 mg/dL
|
3 months:
|
169 - 536 mg/dL
|
4 - 6 months:
|
165 - 781 mg/dL
|
7 - 9 months:
|
282 - 1026 mg/dL
|
10 months - 1 year:
|
331 - 1165 mg/dL
|
2 years:
|
407 - 1009 mg/dL
|
3 years:
|
423 - 1090 mg/dL
|
4 - 5 years:
|
445 - 1187 mg/dL
|
6 - 8 years:
|
608 - 1229 mg/dL
|
9 - 10 years:
|
584 - 1509 mg/dL
|
>10 years:
|
734 - 1570 mg/dL
|
IgG Subclasses:
|
Age:
|
G1 (mg/dL)
|
G2 (mg/dL)
|
G3 (mg/dL)
|
G4 (mg/dL)
|
0 - 3 mos:
|
218 - 496
|
40 - 167
|
4 - 23
|
1 - 33
|
3 - 6 mos:
|
143 - 394
|
23 - 147
|
4 - 100
|
1 - 14
|
6 - 9 mos:
|
190 - 388
|
37 - 60
|
12 - 62
|
0 - 1
|
9 mos - 3 yrs:
|
286 - 680
|
30 – 327
|
13 - 82
|
1 - 65
|
3 - 5 yrs:
|
381 - 884
|
70 - 443
|
17 - 90
|
1 - 116
|
5 - 7 yrs:
|
292 - 816
|
83 - 513
|
8 - 111
|
1 - 121
|
7 - 9 years
|
422 - 802
|
113 - 480
|
15 - 133
|
1 - 84
|
9 - 11 years
|
456 - 938
|
163 - 513
|
26 - 113
|
1 - 121
|
11 - 13 yrs:
|
456 - 952
|
147 - 493
|
12 - 179
|
1 - 121
|
13 - 15 yrs:
|
347 - 993
|
140 - 440
|
23 - 117
|
1 - 83
|
>15 yrs:
|
422 - 1292
|
117 - 747
|
41 - 129
|
1 - 291
|
Critical Values:
|
N/A
|
Limitations:
|
N/A
|
Methodology:
|
Nephelometry, BN Prospec
|
References:
|
N AS IgG 1-2 Package Insert (April 2008) Siemens Healthcare Diagnostics, Newark, DE
|
N Protein Standard SL Package Insert (May 2008) Siemens Healthcare Diagnostics, Newark, DE
|
N Latex IgG3 and N Latex IgG4 Package Insert (April 2008) Siemens Healthcare Diagnostics, Newark, DE
|
