Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

VALPROIC ACID, FREE, LEVEL

General Information

Lab Order Codes:

FVPA

Synonyms:

Unbound Depakene; Depakane; Depakote; Dipropylacetic acid; VPA, Divalproex; Valproate

CPT Codes:

80164 – Dipropylacetic acid (valproic acid)

Test Includes:

Free valproic acid concentration reported in ug/mL.

Logistics

Test Indications:

Valproic acid is used for treatment of seizures. Valproic acid may be used in conjunction with other antiepileptics against tonic-clonic and partial seizures. Peak levels are reached in 1-4 hours. The biologic half-life is about 15 hours.

Lab Testing Sections:

Chemistry - Sendouts

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 – 6 hours for Stat, 1 day for Routine

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube preferred

Alternate tube: Green top (Li Heparin) tube

Draw Volume:

9 mL (Minimum: 3 mL) blood

Processed Volume:

3 mL (Minimum: 1.0 mL) serum/plasma

Note: Submission of the minimum volume does not allow for repeat analysis and may result in a QNS (quantity not sufficient) test result.

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a plastic sample cup. Store at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Unlabeled specimen; specimens other than heparinized plasma/serum

Interpretive

Reference Range:

Therapeutic concentration: 6 - 20 ug/mL

Critical Values:

Toxic concentration: >=40 ug/mL

Limitations:

Reporting Limit: 2.0 ug/ml

Methodology:

Ultrafiltration, Immunoassy (IA)

References:

Medtox Laboratories Web Page May 2010

Updates:

5/6/2010: CPT update, previously reported as 83520.



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