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Lab Dept:
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Chemistry
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Test Name:
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CORTISOL
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General Information
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Lab Order Codes:
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CORTI
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Synonyms:
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N/A
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CPT Codes:
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82533 – Cortisol; total
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Test Includes:
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Serum cortisol measured in ug/dL.
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Logistics
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Test Indications:
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Useful for patients who are not, or are not suspected to be, taking exogenous glucocorticoids. Cortisol is the primary adrenal glucocorticoid steroid hormone and is normally under feedback control by pituitary ACTH and the hypothalamus. Due to circadian variation, random single samples are of little value diagnostically. Reference values for 5 – 11 AM and 5 – 11 PM are published with results at Children's Hospitals and Clinics. Cortisol is elevated in Cushing’s Syndrome, hypoglycemia, stress and pregnancy.
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Lab Testing Sections:
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Chemistry (All specimens tested on the St. Paul campus)
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Phone Numbers:
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MIN Lab: 612-813-6280
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STP Lab: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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Stat: Within 12 hours, performed daily
Routine: 1 - 3 days, performed Monday – Friday (7am – 8pm)
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top (plain, no gel) tube
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Draw Volume:
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1.5 mL (Minimum: 1 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.2 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove plasma/serum aliquot into plastic sample cup. Analyze sample immediately or store at refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimen; grossly hemolyzed; or specimens other than serum
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Interpretive
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Reference Range:
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AM Specimens Reference Ranges (5 – 11 AM):
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Age:
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Range (ug/dL)
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0 – 24 months:
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1.0 – 34.0 ug/dL
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2 – 10 years:
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1.0 – 33.0 ug/dL
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11 – 18 years:
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1.0 – 28.0 ug/dL
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>18 years:
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5.0 – 25.0 ug/dL
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PM Specimen Reference Ranges (5 – 11 PM)
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0 – 24 months:
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1.0 – 30.0 ug/dL
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2 – 11 years:
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1.0 – 24.0 ug/dL
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11 – 18 years:
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1.0 – 22.0 ug/dL
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>18 years:
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3.0 – 16.0 ug/dL
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Competitive Immunoassay using direct chemiluminescence
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References:
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Siemens Healthcare (August 13, 2008) Immulite 2000, Package Insert PN PIL2KCO-ZO
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Tietz (1999) Textbook of Clinical Chemistry, 3rd edition, Philadelphia, WB Saunders Co, pp 1543 - 1546
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Jacobs & DeeMott (2001) Laboratory Test Handbook, 5th edition, Lexi-Comp Inc, Hudson, Ohio, pp 154-155
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Soldin, Brunara, Wong, (2003) Pediatric Reference Ranges, 4th edition
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