Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

METHYLMALONIC ACID (MMA), SERUM

General Information

Lab Order Codes:

MMA

Synonyms:

MMA

CPT Codes:

83921 – Organic acid, single, quantitative

Test Includes:

Quantitative MMA level reported in nmol/L.

Logistics

Test Indications:

Evaluating children with signs and symptoms of methylmalonic Acidemia. Screening for the differential diagnosis of signs and symptoms associated with a variety of causes of cobalamin deficiency. Serum MMA may be a more reliable marker of cobalamin deficiency than direct cobalamin determination.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 80289/MMAS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 - 5 days, test performed Monday - Friday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube preferred

Draw Volume:

4.5 mL (Minimum: 2.4 mL) blood

Processed Volume:

1.5 mL (Minimum: 0.8 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; unlabeled or mislabeled specimens

Interpretive

Reference Range:

< or = 0.40 nmol/L

In pediatric patients, markedly elevated MMA values are consistent with a diagnosis of methylmalonic acidemia.

In adults, moderately time elevated values are indicative of cobalamin deficiency.

Critical Values:

N/A

Limitations:

Diet, nutritional status, and age should be considered in the evaluation of serum MMA level.

Methodology:

Liquid chromatography-tandem mass spectrometry stable isotope dilution analysis (LC-MS/MS).

References:

Mayo Medical Laboratories April 2011

Updates:

4/18/2011: Storage temp changed from frozen to refrigerated.



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