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Lab Dept:
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Chemistry
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Test Name:
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FATTY ACID PROFILE, MITOCHONDRIAL
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General Information
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Lab Order Codes:
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FAPM
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Synonyms:
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Fatty Acid Profile, Mitochondrial (C8-C18), Serum
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CPT Codes:
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82544 – Column chromatography/mass spectrometry, analyte not elsewhere specified; stable isotope dilution, multiple analytes, quantitative, single stationary and mobile phase
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Test Includes:
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See Reference Range
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Logistics
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Test Indications:
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Useful for biochemical diagnoses inborn errors of mitochondrial fatty acid oxidation, including deficiencies of medium-chain acyl-Co-A dehydrogenase, long-chain acyl-Co A dehydrogenase, and glutaricacidemia type 2.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# 81939)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test set up Monday - Friday
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Special Instructions:
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See Patient Preparation
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Red top tube
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Draw Volume:
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2 mL (Minimum: 0.5 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.15 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen and aliquot serum into a plastic screw- capped round bottom vial. Store and ship at frozen temperatures. Forward promptly.
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Patient Preparation:
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Overnight (12-14 hour) fast recommended. Patient must not consume any alcohol for 24 hours before the specimen is drawn.
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Sample Rejection:
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Specimens other than serum or plasma, anticoagulants other than EDTA or heparin, warm specimens
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Interpretive
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Reference Range:
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Fatty Acid nmol/mL
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1 - 31 days
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32 days - 1 year
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2 - 17 years
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≥18 years
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Octanoic Acid, C8:0
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7 - 63
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7 - 63
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9 - 41
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8 - 47
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Decenoic Acid, C10:1
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0.8 - 4.8
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0.8 - 4.8
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1.6 - 6.6
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1.8 - 5.0
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Decanoic Acid, C10:0
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2 - 62
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2 - 62
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3 - 25
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2 - 18
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Lauroleic Acid, C12:1
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0.6 - 4.8
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0.6 - 4.8
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1.3 - 5.8
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1.4 - 6.6
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Lauric Acid, C12:0
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6 - 190
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6 - 190
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5 - 80
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6 - 90
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Tetradecadienoic Acid, C14:2
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0.3 - 6.5
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0.3 - 6.5
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0.2 - 5.8
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0.8 - 5.0
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Myristoleic Acid, C14:1
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1 - 46
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1 - 46
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1 – 31
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3 - 64
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Myristic Acid, C14:0
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30 - 320
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30 - 320
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40 - 290
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30 - 450
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Hexadecadienoic Acid, C16:2
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4 - 27
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4 - 27
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3 - 29
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10 - 48
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Palmitoleic Acid, C16:1w7
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20 - 1020
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20 - 1020
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100 - 670
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110 - 1130
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Palmitic Acid, C16:0
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720 - 3120
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720 - 3120
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960 - 3460
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1480 - 3730
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Linoleic Acid, C18:2w6
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350 - 2660
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1000 - 3300
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1600 - 3500
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2270 - 3850
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Oleic Acid, C18:1w9
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250 - 3500
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250 - 3500
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350 - 3500
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650 - 3500
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Stearic Acid, C18:0
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270 - 1140
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270 - 1140
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280 - 1170
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590 - 1170
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Critical Values:
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N/A
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Limitations:
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For nutritional assessment, a 12-14 hour fast is required.
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Methodology:
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Capillary gas chromatography/Mass spectrometry, Stable isotope dilution.
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References:
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Mayo Medical Laboratories Web Page December 2010
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Updates:
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12/23/2010: Updated units, no change in reference ranges.
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