Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

FATTY ACID PROFILE, MITOCHONDRIAL

General Information

Lab Order Codes:

FAPM

Synonyms:

Fatty Acid Profile, Mitochondrial (C8-C18), Serum

CPT Codes:

82544 – Column chromatography/mass spectrometry, analyte not elsewhere specified; stable isotope dilution, multiple analytes, quantitative, single stationary and mobile phase

Test Includes:

See Reference Range

Logistics

Test Indications:

Useful for biochemical diagnoses inborn errors of mitochondrial fatty acid oxidation, including deficiencies of medium-chain acyl-Co-A dehydrogenase, long-chain acyl-Co A dehydrogenase, and glutaricacidemia type 2.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 81939/FAPM)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test set up Monday – Friday; not reported Saturday or Sunday

Special Instructions:

See Patient Preparation

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

2 mL (Minimum: 0.5 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.15 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen within 45 minutes of collection and aliquot serum into a plastic screw- capped round bottom vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

Overnight (12-14 hour) fast recommended. Patient must not consume any alcohol for 24 hours before the specimen is drawn.

Sample Rejection:

Specimens other than serum or plasma; anticoagulants other than EDTA or heparin; warm specimens; gross lipemia

Interpretive

Reference Range:

Fatty Acid nmol/mL

1 - 31 days

32 days - 1 year

2 - 17 years

≥18 years

Octanoic Acid, C8:0

7 - 63

7 - 63

9 - 41

8 - 47

Decenoic Acid, C10:1

0.8 - 4.8

0.8 - 4.8

1.6 - 6.6

1.8 - 5.0

Decanoic Acid, C10:0

2 - 62

2 - 62

3 - 25

2 - 18

Lauroleic Acid, C12:1

0.6 - 4.8

0.6 - 4.8

1.3 - 5.8

1.4 - 6.6

Lauric Acid, C12:0

6 - 190

6 - 190

5 - 80

6 - 90

Tetradecadienoic Acid, C14:2

0.3 - 6.5

0.3 - 6.5

0.2 - 5.8

0.8 - 5.0

Myristoleic Acid, C14:1

1 - 46

1 - 46

1 – 31

3 - 64

Myristic Acid, C14:0

30 - 320

30 - 320

40 - 290

30 - 450

Hexadecadienoic Acid, C16:2

4 - 27

4 - 27

3 - 29

10 - 48

Palmitoleic Acid, C16:1w7

20 - 1020

20 - 1020

100 - 670

110 - 1130

Palmitic Acid, C16:0

720 - 3120

720 - 3120

960 - 3460

1480 - 3730

Linoleic Acid, C18:2w6

350 - 2660

1000 - 3300

1600 - 3500

2270 - 3850

Oleic Acid, C18:1w9

250 - 3500

250 - 3500

350 - 3500

650 - 3500

Stearic Acid, C18:0

270 - 1140

270 - 1140

280 - 1170

590 - 1170

Interpretation: Fatty acid oxidation disorders are recognized on the basis of disease-specific metabolite patterns that are correlated to the results of other investigations in plasma (carnitine, acylcarnitines) and urine (organic acids, acylglycines).

Critical Values:

N/A

Limitations:

For nutritional assessment, a 12-14 hour fast is required.

Methodology:

Capillary gas chromatography/Mass spectrometry, Stable isotope dilution.

References:

Mayo Medical Laboratories Web Page July 2013

Updates:

12/23/2010: Updated units, no change in reference ranges.



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