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Lab Dept:
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Chemistry
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Test Name:
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CANCER ANTIGEN 125 (CA 125)
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General Information
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Lab Order Codes:
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C125
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Synonyms:
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CA 125; Carbohydrate Antigen 125; Ovarian Cancer-Related Antibodies
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CPT Codes:
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86304 – CA 125
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Test Includes:
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CA 125 level measured in U/mL.
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Logistics
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Test Indications:
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Useful for evaluating patients’ response to cancer therapy, especially for ovarian carcinoma. Predicting recurrent ovarian cancer or intraperitoneal tumor.
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Lab Testing Sections:
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Chemistry – Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# 9289)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1-3 days, test performed Monday - Saturday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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1.8 mL (Minimum: 0.6 mL) blood
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Processed Volume:
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0.6 mL (Minimum: 0.5 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped, round bottom plastic vial. Store and ship at refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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<35 U/mL
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Critical Values:
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N/A
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Limitations:
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Not useful as a screening assay for cancer detection in the normal population. Results cannot be interpreted as absolute evidence of the presence or absence of disease. Serum markers are not specific for malignancy and values vary by method. Values obtained with different assay methods cannot be used interchangeably.
Some individuals have antibodies to mouse protein (HAMA) which can cause interference in immunoassays that employ mouse antibodies. In particular, it has been reported that serum samples from patients who have undergone therapeutic or diagnostic procedures that include infusion of mouse monoclonal antibodies may produce erroneous results in such assays. Rerunning the specimen in question after additional blocking treatment may resolve the issue.
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Methodology:
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Automated immunoassay
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References:
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Mayo Medical Laboratory May 2010
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Updates:
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5/11/2010: Volume update.
6/16/2010: Shipping temp changed from frozen to refrigerated. Frozen will still be accepted, refrigerated is preferred.
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