Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

INFLIXIMAB/HACA MEASUREMENT

General Information

Lab Order Codes:

INHA

Synonyms:

N/A

CPT Codes:

83520 x2 – Immunoassay analyte, quantitative, not otherwise specified

Test Includes:

Serum Infliximab and HACA (Human Anti-Chimeric AB) reported in mcg/mL.

Logistics

Test Indications:

Serum infliximab measurement is necessary when assessing the presence or absence of HACA. Serum infliximab concentrations may vary among equally dosed patient. Measuring serum infliximab levels can aid physicians in determining the dose of infliximab and guide infusion intervals. The HACA portion of the test detects Human Anti-Chimeric Antibodies (antibodies against infliximab). Patients that develop HACA may experience infusion reactions and/or a reduced duration of efficacy of infliximab.

Lab Testing Sections:

Serology – Sendouts

Referred to:

Prometheus Laboratory (Prometheus Test: 3130)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

8 – 10 days

Special Instructions:

N/A

Specimen

Specimen Type:

Whole blood

Container:

Red top tube

Draw Volume:

6 mL blood

Processed Volume:

2 mL serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship frozen. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

Infliximab:

<1.40 mcg/mL

Human Anti-Chimeric Ab (HACA):

<1.69 mcg/mL

Critical Values:

N/A

Limitations:

N/A

Methodology:

Elisa

References:

Prometheus Laboratory May 2008



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