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Lab Dept:
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Chemistry
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Test Name:
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INFLIXIMAB/HACA MEASUREMENT
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General Information
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Lab Order Codes:
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INHA
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Synonyms:
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N/A
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CPT Codes:
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83520 x2 – Immunoassay analyte, quantitative, not otherwise specified
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Test Includes:
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Serum Infliximab and HACA (Human Anti-Chimeric AB) reported in mcg/mL.
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Logistics
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Test Indications:
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Serum infliximab measurement is necessary when assessing the presence or absence of HACA. Serum infliximab concentrations may vary among equally dosed patient. Measuring serum infliximab levels can aid physicians in determining the dose of infliximab and guide infusion intervals. The HACA portion of the test detects Human Anti-Chimeric Antibodies (antibodies against infliximab). Patients that develop HACA may experience infusion reactions and/or a reduced duration of efficacy of infliximab.
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Lab Testing Sections:
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Serology – Sendouts
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Referred to:
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Prometheus Laboratory (Prometheus Test# 3130)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6500
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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8 – 10 days
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Red top tube
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Draw Volume:
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6 mL blood
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Processed Volume:
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2 mL of serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship frozen. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimen
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Interpretive
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Reference Range:
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Infliximab:
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<1.40 mcg/mL
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Human Anti-Chimeric Ab (HACA):
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<1.69 mcg/mL
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Elisa
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Contraindications:
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N/A
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References:
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Prometheus Laboratory May 2008
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