Clinics and Departments

Laboratory Services

Lab Dept:


Test Name:


General Information

Lab Order Codes:



Neopterin, CSF

CPT Codes:

82491 – Chromatography, quantitative, column, single analyte not elsewhere specified, single stationary and mobile phase

Test Includes:

CSF Neopterin level reported in nmol/L.


Test Indications:

Neopterin is a catabolic product of guanosine triphosphate (GTP) and the synthesis of tetrahydrobiopterin (BH4). It is predominantly produced by macrophages and measurement in cerebrospinal fluid provides information about activation of the cellular immune system. Increased neopterin production is found in, but not limited to: viral infections including HIV, bacterial infections, autoimmune disease and malignant tumor diseases. Changes in CSF neopterin may also occur in deficiency of the BH4 synthesis pathway.

Lab Testing Sections:

Sendouts - Chemistry

Referred to:

Mayo Medical Laboratories (Test: 90492) forward to Baylor University Medical Center, Dallas, TX

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

7-10 days

Special Instructions:

Collect specimen on ice and send to the laboratory immediately.


Specimen Type:



Spinal fluid conical tube

Draw Volume:

3.5 mL (Minimum: 0.5 mL) spinal fluid

Processed Volume:

Same as Draw Volume


Routine spinal fluid collection. Collect specimen on ice and send to the laboratory immediately.

Special Processing:

Lab Staff: Spinal fluid must be aliquoted into Mayo Supply T612. This supply kit consists of 5 microcentrifuge tubes in a cardboard holder. The kit contains specific instructions on how each microcentrifuge tube should be filled. If the spinal fluid is contaminated with blood, it should be centrifuged immediately and then transferred into the microcentrifuge tubes as directed. One set of tubes is required per spinal fluid collection.

Freeze immediately at –70 centigrade and ship frozen. Order through the Mayo Access, Mayo unit code: 90492. Mayo will hold for delivery to Baylor Monday-Thursday.

Note: If 3.5 mL is not obtained, 0.5 mL of spinal fluid frozen in a standard aliquot tube can be tested, but no additional testing can be performed.

Patient Preparation:


Sample Rejection:

Thawed specimen; hemolyzed specimens; mislabeled or unlabeled specimens


Reference Range:

7 – 65 nmol/L

Critical Values:



HPLC with fluorescence detection


Mayo Medical Laboratories October 2010


Institute of Metabolic Disease, Baylor Research Institute October 2010

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