Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

NEOPTERIN, SPINAL FLUID

General Information

Lab Order Codes:

NEOP

Synonyms:

Neopterin, CSF

CPT Codes:

82491 – Chromatography, quantitative, column, single analyte not elsewhere specified, single stationary and mobile phase

Test Includes:

CSF Neopterin level reported in nmol/L.

Logistics

Test Indications:

Neopterin is a catabolic product of guanosine triphosphate (GTP) and the synthesis of tetrahydrobiopterin (BH4). It is predominantly produced by macrophages and measurement in cerebrospinal fluid provides information about activation of the cellular immune system. Increased neopterin production is found in, but not limited to: viral infections including HIV, bacterial infections, autoimmune disease and malignant tumor diseases. Changes in CSF neopterin may also occur in deficiency of the BH4 synthesis pathway.

Lab Testing Sections:

Sendouts - Chemistry

Referred to:

Mayo Medical Laboratories (Test: 90492) forward to Baylor University Medical Center, Dallas, TX

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

7-10 days

Special Instructions:

Collect specimen on ice and send to the laboratory immediately.

Specimen

Specimen Type:

CSF

Container:

Spinal fluid conical tube

Draw Volume:

3.5 mL (Minimum: 0.5 mL) spinal fluid

Processed Volume:

Same as Draw Volume

Collection:

Routine spinal fluid collection. Collect specimen on ice and send to the laboratory immediately.

Special Processing:

Lab Staff: Spinal fluid must be aliquoted into Mayo Supply T612. This supply kit consists of 5 microcentrifuge tubes in a cardboard holder. The kit contains specific instructions on how each microcentrifuge tube should be filled. If the spinal fluid is contaminated with blood, it should be centrifuged immediately and then transferred into the microcentrifuge tubes as directed. One set of tubes is required per spinal fluid collection.

Freeze immediately at –70 centigrade and ship frozen. Order through the Mayo Access, Mayo unit code: 90492. Mayo will hold for delivery to Baylor Monday-Thursday.

Note: If 3.5 mL is not obtained, 0.5 mL of spinal fluid frozen in a standard aliquot tube can be tested, but no additional testing can be performed.

Patient Preparation:

None

Sample Rejection:

Thawed specimen; hemolyzed specimens; mislabeled or unlabeled specimens

Interpretive

Reference Range:

7 – 65 nmol/L

Critical Values:

N/A

Methodology:

HPLC with fluorescence detection

References:

Mayo Medical Laboratories October 2010

 

Institute of Metabolic Disease, Baylor Research Institute October 2010



  Lab Test Directory
    Chemistry
    Coagulation
    Flow/Immunology
    Hematology
    Microbiology/ Virology
    Other Fluids
    Pathology
    Serology
    Transfusion Services
    Urine/Stool

  Search Lab Test Directory
    List All Documents

  Lab Staff

  E-mail Lab Services