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Lab Dept:
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Chemistry
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Test Name:
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TACROLIMUS (FK506) LEVEL (FOR TRANSPLANT PATIENTS)
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General Information
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Lab Order Codes:
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TACU
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Synonyms:
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FK506; Prograf®
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CPT Codes:
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No charge, if the transplant was at the UM
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Test Includes:
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Tacrolimus level reported in ug/L.
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Logistics
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Test Indications:
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Useful for guiding dosage adjustments to achieve optimal immunosuppression while minimizing dose-dependant toxicity.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Fairview University Labs (Fairview Code: TACR)
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Phone Numbers:
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MIN: 612-813-6280
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STP: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 2 days, test performed daiIy; results are reported the same day
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Special Instructions:
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Usual sampling time is prior to next dose.
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Lavender top (EDTA) tube
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Draw Volume:
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2 mL (Minimum: 0.4 mL) blood
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Processed Volume:
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Same as Draw Volume
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Do Not centrifuge. Specimen should remain as whole blood in original collection container. Store in refrigerator. Do Not order test in Atlas. Ship at room temperature. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Therapeutic range based on draw immediately prior to next dose.
Default Therapeutic Reference Range: 5.0 – 15.0 ug/L
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Kidney Transplant
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Range (ug/L)
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Pediatric
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0 – 3 months post transplant
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10 - 12
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3 – 6 months post transplant
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8 – 10
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6 – 12 months post transplant
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6 – 8
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>12 months post transplant
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4 – 7
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Adult
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0 – 6 months post transplant
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8 – 10
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6 – 12 months post transplant
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6 – 8
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>12 months post transplant
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4 – 6
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>5 years post transplant
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3 – 5
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Heart Transplant
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Range (ug/L)
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Pediatric
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0 – 12 months post transplant
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10 – 15
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>12 months post transplant
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5 – 10
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Adult
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0 – 3 months post transplant
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10 – 15
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3 – 6 months post transplant
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8 – 12
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6 – 12 months post transplant
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6 – 12
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>12 months post transplant
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6 – 10
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Lung Transplant
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Range (ug/L)
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0 – 12 months post transplant
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10 – 15
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>12 months post transplant
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8 – 12
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Liver Transplant
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Range (ug/L)
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Pediatric
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0 – 3 months post transplant
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10 – 12
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3 – 6 months post transplant
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8 – 10
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>6 months post transplant
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6 – 8
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Adult
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0 – 3 months post transplant
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10 – 12
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3 – 6 months post transplant
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8 – 10
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>6 months post transplant
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6 – 8
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Pancreas Transplant
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Range (ug/L)
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0 – 6 months post transplant
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8 – 10
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>6 months post transplant
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5 – 8
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Critical Values:
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>20 ug/L
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Limitations:
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The recommended therapeutic range applies to trough specimens drawn just before the next dose. Blood collected at other times will yield higher results.
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Methodology:
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Liquid Chromatography/Tandem Mass Spectrophotometry (HPLC-MS/MS)
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References:
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Fairview-University Web Page November 2012
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Updates:
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7/3/2009: Reference range change, previously reported as 10-20 ug/L. Critical value change, previously reported as >40 ug/L
11/12/2012: Reference range update.
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