Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

TACROLIMUS (FK506) LEVEL (FOR TRANSPLANT PATIENTS)

General Information

Lab Order Codes:

TACU

Synonyms:

FK506; Prograf®

CPT Codes:

No charge, if the transplant was at the UM

Test Includes:

Tacrolimus level reported in ug/L.

Logistics

Test Indications:

Useful for guiding dosage adjustments to achieve optimal immunosuppression while minimizing dose-dependant toxicity.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Fairview University Labs (Fairview Code: TACR)

Phone Numbers:

MIN: 612-813-6280

STP: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 2 days, test performed daiIy; results are reported the same day

Special Instructions:

Usual sampling time is prior to next dose.

Specimen

Specimen Type:

Whole blood

Container:

Lavender top (EDTA) tube

Draw Volume:

2 mL (Minimum: 0.4 mL) blood

Processed Volume:

Same as Draw Volume

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Do Not centrifuge. Specimen should remain as whole blood in original collection container. Store in refrigerator. Do Not order test in Atlas. Ship at room temperature. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Therapeutic range based on draw immediately prior to next dose.
Default Therapeutic Reference Range: 5.0 – 15.0 ug/L

Kidney Transplant

Range (ug/L)

Pediatric

0 – 3 months post transplant

10 - 12

3 – 6 months post transplant

8 – 10

6 – 12 months post transplant

6 – 8

>12 months post transplant

4 – 7

Adult

0 – 6 months post transplant

8 – 10

6 – 12 months post transplant

6 – 8

>12 months post transplant

4 – 6

>5 years post transplant

3 – 5

Heart Transplant

Range (ug/L)

Pediatric

0 – 12 months post transplant

10 – 15

>12 months post transplant

5 – 10

Adult

0 – 3 months post transplant

10 – 15

3 – 6 months post transplant

8 – 12

6 – 12 months post transplant

6 – 12

>12 months post transplant

6 – 10

Lung Transplant

Range (ug/L)

0 – 12 months post transplant

10 – 15

>12 months post transplant

8 – 12

Liver Transplant

Range (ug/L)

Pediatric

0 – 3 months post transplant

10 – 12

3 – 6 months post transplant

8 – 10

>6 months post transplant

6 – 8

Adult

0 – 3 months post transplant

10 – 12

3 – 6 months post transplant

8 – 10

>6 months post transplant

6 – 8

Pancreas Transplant

Range (ug/L)

0 – 6 months post transplant

8 – 10

>6 months post transplant

5 – 8

Critical Values:

>20 ug/L

Limitations:

The recommended therapeutic range applies to trough specimens drawn just before the next dose. Blood collected at other times will yield higher results.

Methodology:

Liquid Chromatography/Tandem Mass Spectrophotometry (HPLC-MS/MS)

References:

Fairview-University Web Page November 2012

Updates:

7/3/2009: Reference range change, previously reported as 10-20 ug/L. Critical value change, previously reported as >40 ug/L
11/12/2012: Reference range update.



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