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Lab Dept:
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Chemistry
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Test Name:
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TIAGABINE LEVEL
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General Information
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Lab Order Codes:
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TIAG
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Synonyms:
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Gabitril®
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CPT Codes:
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82542 – Column chromatography/mass spectrometry quantitative
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Test Includes:
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Tiagabine (Gabitril®) level measured in ng/mL.
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Logistics
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Test Indications:
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Antiepileptic (anticonvusant) drug monitoring
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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MedTox Laboratories (Test # 409)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 days
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Special Instructions:
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Trough levels are most reproducible.
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
Alternate tube: Green top tube
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Draw Volume:
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9.0 mL (Minimum: 4.5 mL) blood
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Processed Volume:
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3.0 mL (Minimum: 1.5 mL) serum/plasma
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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<235.0 ng/mL
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Critical Values:
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N/A
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Limitations:
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Reporting limit: 5.0 ng/mL
Therapeutic and toxic ranges have not been established. Peak concentrations are expected at 45 minutes post dose: steady state is generally attained within 2 days. Observed tiagabine concentrations in clinical trials (30-56 mg/day): <1-234 ng/mL. Measured tiagabine concentrations post marketing (95% confidence interval): 0-440 ng/mL. Note: The 95% confidence interval for tiagabine concentrations determined by MEDTOX Laboratories will be updated periodically as more information becomes available.
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Methodology:
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Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).
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References:
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MedTox Laboratories Web Page March 2009
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