Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

TIAGABINE LEVEL

General Information

Lab Order Codes:

TIAG

Synonyms:

Gabitril®

CPT Codes:

82542 – Column chromatography/mass spectrometry quantitative

Test Includes:

Tiagabine (Gabitril®) level measured in ng/mL.

Logistics

Test Indications:

Antiepileptic (anticonvusant) drug monitoring

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

MedTox Laboratories (MedTox Test: 409)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 days

Special Instructions:

Trough levels are most reproducible.

Specimen

Specimen Type:

Blood

Container:

Red top tube
Alternate tube: Green top tube

Draw Volume:

9 mL (Minimum: 4.5 mL) blood

Processed Volume:

3 mL (Minimum: 1.5 mL) serum/plasma

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

<235.0 ng/mL

Critical Values:

N/A

Limitations:

Reporting limit: 5.0 ng/mL

Therapeutic and toxic ranges have not been established. Peak concentrations are expected at 45 minutes post dose: steady state is generally attained within 2 days. Observed tiagabine concentrations in clinical trials (30-56 mg/day): <1-234 ng/mL. Measured tiagabine concentrations post marketing (95% confidence interval): 0-440 ng/mL. Note: The 95% confidence interval for tiagabine concentrations determined by MEDTOX Laboratories will be updated periodically as more information becomes available.

Methodology:

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).

References:

MedTox Laboratories March 2009



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