Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

S-ADENOSYLMETHIONINE (SAMe) & S-ADENOSYLHOMOCYSTEINE (SAH), BLOOD

General Information

Lab Order Codes:

SAMH

Synonyms:

SAMe; SAH

CPT Codes:

83789 – Mass spectrometry and tandem mass spectrometry (MS, MS/MS); quantitative analyte not elsewhere specified.

Test Includes:

SAMe & SAH levels reported in nmol/L.

Logistics

Test Indications:

S-adenosylhomocysteine (SAH) is a by-product of all methylation reactions and is rapidly metabolized to homocysteine. Increased levels of SAH may occur when the intracellular concentration of homocysteine increases. Since SAH has been show to inhibit methylation dependent reactions the ratio of S-adenosylmethionine (SAM) to SAH is often used as an index of methylation status.

S-adenosylmethionine (SAMe) is the major methyl donor in numerous methylation reactions such as proteins, DNA, phospholipids and neurotransmitters. Decreased levels of SAMe commonly occur in the presence of folate and cobalamin (vitamin B12) deficiency. Low SAMe levels have been associated with depression, dementia, vacuolar myelopathy and liver disease.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Baylor Institute of Metabolic Disease

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

14 days

Special Instructions:

This research test must be coordinated through the Neuropharmacology Laboratory Director. Most research tests are performed on a batch basis; the laboratory will not perform single sample testing. Contact the Neuropharmacology Laboratory Director for more information.

Please include information for patient regarding: current medications and relevant patient history.

Specimen

Specimen Type:

Blood

Container:

Green top tube

Draw Volume:

1 mL blood

Processed Volume:

0.25 mL plasma

Collection:

Routine venipuncture

Special Processing:

N/A

Patient Preparation:

Lab Staff: Centrifuge specimen within 1 hour of collection, remove plasma aliquot into a screw-capped round bottom plastic vial. Store at –70 C until transport. Ship sample overnight Monday – Wednesday ONLY with 3-4 lbs of dry ice using guaranteed overnight courier. Contact reference lab prior to sending. Forward promptly.

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

Test:

Reference range (nmol/L):

SAMe:

33.0 – 94.8 nmol/L

SAH:

13.2 – 28.2 nmol/L

Critical Values:

N/A

Limitations:

Research categorized test

Methodology:

HPLC and UV detection

References:

Institute of Metabolic Disease at Baylor Research Institute March 2009



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