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Lab Dept:
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Chemistry
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Test Name:
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MYCOPHENOLIC ACID LEVEL
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General Information
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Lab Order Codes:
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MPA
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Synonyms:
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MPA; CellCept; Mycophenolate Mofetil
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CPT Codes:
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80299 - Quantitation of drug, not elsewhere specified
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Test Includes:
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Mycophenolic Acid and MPA Glucuronide levels reported in mcg/mL.
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Logistics
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Test Indications:
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Monitoring therapy with CellCept to ensure adequate blood levels and avoid overimmunosuppression.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 81563)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1- 3 days, performed daily
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Special Instructions:
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Serum gel tubes can not be used for collection.
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top (plain, no gel) tube
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Draw Volume:
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3 mL (Minimum: 0.3 mL) blood
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Processed Volume:
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1 mL (Minimum: 0.1 mL) serum
Note: Submission of the minimum volume does not allow for repeat analysis and may result in a QNS (quantity not sufficient) test result.
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens; incorrect specimen type
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Interpretive
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Reference Range:
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Mycophenolic Acid:
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1.0 – 3.5 mcg/mL
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MPA Glucuronide:
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35 – 100 mcg/mL
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Critical Values:
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N/A
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Limitations:
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Correct interpretation requires a trough serum specimen (just before the next regular dose). Specimens drawn at other times in the dosing cycle are likely to have higher MPA levels. In these cases, the reference range does not apply.
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Methodology:
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Tandem Mass Spectrophotometry (MS/MS)
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References:
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Mayo Medical Laboratories Web Page (August 2010)
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