Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

MYCOPHENOLIC ACID LEVEL

General Information

Lab Order Codes:

MPA

Synonyms:

MPA; CellCept; Mycophenolate Mofetil

CPT Codes:

80299 - Quantitation of drug, not elsewhere specified

Test Includes:

Mycophenolic Acid and MPA Glucuronide levels reported in mcg/mL.

Logistics

Test Indications:

Monitoring therapy with CellCept to ensure adequate blood levels and avoid overimmunosuppression.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 81563/MPA)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1- 3 days, performed daily

Special Instructions:

Serum gel tubes can not be used for collection.

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube

Draw Volume:

3 mL (Minimum: 0.3 mL) blood

Processed Volume:

1 mL (Minimum: 0.1 mL) serum

Note: Submission of the minimum volume does not allow for repeat analysis and may result in a QNS (quantity not sufficient) test result.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens; incorrect specimen type

Interpretive

Reference Range:

Mycophenolic Acid:

1.0 – 3.5 mcg/mL

MPA Glucuronide:

35 – 100 mcg/mL

Critical Values:

N/A

Limitations:

Correct interpretation requires a trough serum specimen (just before the next regular dose). Specimens drawn at other times in the dosing cycle are likely to have higher MPA levels. In these cases, the reference range does not apply.

Methodology:

Tandem Mass Spectrophotometry (MS/MS)

References:

Mayo Medical Laboratories (August 2010)



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