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Lab Dept:
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Chemistry
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Test Name:
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METHOTREXATE POLYGLUTAMATE
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General Information
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Lab Order Codes:
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MTXP
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Synonyms:
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Avise PG
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CPT Codes:
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82491 – Chromatography, quantative, column; single analyte not elaewhere specified, single stationary and mobile phase
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Test Includes:
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Measures red blood cell methotrexate polyglutamates (MTX PGs), the active metabolites of methotrexate.
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Logistics
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Test Indications:
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Avise PG testing service is a specialized blood test that helps measure how well your body metabolizes methotrexate (MTX). MTX is a widely used medication for the treatment of rheumatoid arthritis (RA) and may be prescribed alone or in combination with other therapies. However, not everyone responds to MTX therapy in the same way, so some patients need a higher dose while others do fine on a lower dose.
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Lab Testing Sections:
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Chemistry - Sendouts
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Referred to:
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Exagen Diagnostics (Exagen Test: Avise PG)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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7 – 10 days
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole Blood
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Container:
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Lavender top (EDTA) tube provided in kit
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Draw Volume:
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5 mL blood
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Processed Volume:
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Do not centrifuge. Call overnight carrier to arrange for pickup according to shipping label provided in kit. Samples drawn Monday-Friday should be shipped overnight priority delivery the same day. Saturday deliveries are acceptable. If shipment is delayed, store refrigerated. The specimen may be stored up to 4 days before shipping.
When ready to ship:
1. Insert frozen cold pack into large well.
2. Enclose specimen(s) in small plastic bag(s) and place inside small wells, away from coldpack.
3. Samples from multiple patients may be placed in the same box.
4. Replace foam lid and place the completed test requisition(s) on top before closing transportation kit.
5. Affix the shipping label provided to the large shipping bag.
6. Place the closed transportation kit inside the shipping bag and seal.
Ship to:
Exagen Diagnostics, Inc.
1260 Liberty Way Ste C
Vista, CA 92081
Phone: 1-888-452-4522
http://www.avisetest.com
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Therapeutic:
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>60 nmol/L
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Intermediate:
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20.0 – 60.0 nmol/L
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Sub-therapeutic:
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<20 nmol/L
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Liquid chromatographic method with post column photo-oxidation technique
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References:
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Exagen Diagnostics Avise October 2012
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