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Lab Dept:
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Chemistry
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Test Name:
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LACOSAMIDE LEVEL
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General Information
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Lab Order Codes:
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LCS
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Synonyms:
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Vimpat; Desmethyllacosamide
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CPT Codes:
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82542 – Column chromatography/mass spectrometry (eg. GC/MS or HPLC/MS), analyte not elsewhere specified; quantitative, single stationary and mobile phase.
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Test Includes:
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Lacosamide/Vimpat (Desmethyllacosamide) concentration in reported in ug/mL.
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Logistics
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Test Indications:
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Useful for therapeutic drug monitoring (TDM). Lacosamide is used in the treatment of certain types of seizures.
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Lab Testing Sections:
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Chemistry – Sendouts
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Referred to:
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Medtox Laboratories (Test: 777)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily; 24 hours
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Turnaround Time:
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2 – 4 days
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Special Instructions:
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Trough levels are most reproducible
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Specimen
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Specimen Type:
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Blood
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Container:
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Green (Lithium heparin) top tube preferred or Red (no gel) top tube
(Plasma or serum gel tubes are not acceptable)
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Draw Volume:
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3 mL blood
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Processed Volume:
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1 mL plasma/serum
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Collection:
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Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.
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Special Processing:
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Lab Staff: Centrifuge specimen, remove plasma/serum aliquot into plastic sample cup. Store Refrigerated. (Frozen OK. Ambient 3 days OK) Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Unlabeled or mislabeled specimen; specimens other than plasma/serum
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Interpretive
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Reference Range:
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<=15.0 ug/mL
Expected concentrations in patients receiving recommended daily dosages: up to 15.0 ug/mL.
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Critical Values:
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Toxic range not established
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Limitations:
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N/A
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Methodology:
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Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
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References:
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Medtox Laboratories November 2012
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Updates:
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11/1/2012: Reference range update.
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