Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

LACOSAMIDE LEVEL

General Information

Lab Order Codes:

LCS

Synonyms:

Vimpat; Desmethyllacosamide

CPT Codes:

82542 – Column chromatography/mass spectrometry (eg. GC/MS or HPLC/MS), analyte not elsewhere specified; quantitative, single stationary and mobile phase.

Test Includes:

Lacosamide/Vimpat (Desmethyllacosamide) concentration in reported in ug/mL.

Logistics

Test Indications:

Useful for therapeutic drug monitoring (TDM). Lacosamide is used in the treatment of certain types of seizures.

Lab Testing Sections:

Chemistry – Sendouts

Referred to:

Medtox Laboratories (MedTox Test: 777)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily; 24 hours

Turnaround Time:

2 – 4 days

Special Instructions:

Trough levels are most reproducible

Specimen

Specimen Type:

Blood

Container:

Green (Lithium heparin) top tube preferred or
Red (no gel) top tube
(Plasma or serum gel tubes are not acceptable)

Draw Volume:

3 mL blood

Processed Volume:

1 mL plasma/serum

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove plasma/serum aliquot into plastic sample cup. Store Refrigerated. (Frozen OK. Ambient 3 days OK) Forward promptly.

Patient Preparation:

None

Sample Rejection:

Unlabeled or mislabeled specimen; specimens other than plasma/serum

Interpretive

Reference Range:

<=15.0 ug/mL

Expected concentrations in patients receiving recommended daily dosages: up to 15.0 ug/mL.

Critical Values:

Toxic range not established

Limitations:

N/A

Methodology:

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

References:

Medtox Laboratories November 2012

Updates:

11/1/2012: Reference range update.



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